Breast Cancer
Conditions
Keywords
breast cancer, CSCs, ALDH1A1
Brief summary
ALDH1A1 isozyme oxidizes Retinaldehyde to retinoic acid, which regulates the expression of the genes involved in tumor-initiating stem-like cells, thereby initiating tumor growth and resistance to drugs. Much emphasis has been focused on ALDH1A1 as a CSC marker. High expression of ALDH1A1 has been reported as a poor prognostic marker in several tumor types and is associated with poor patient outcomes .
Detailed description
Breast cancer is one of the most common cancers among women. it is a heterogenous disease. several factors affect the prognosis of breast cancer. CSCs markers are one of the emerging prognostic biomarkers. ALDH1A1 isozyme oxidizes Retinaldehyde to retinoic acid, which regulates the expression of the genes involved in tumor-initiating stem-like cells, thereby initiating tumor growth and resistance to drugs. Much emphasis has been focused on ALDH1A1 as a CSC marker. High expression of ALDH1A1 has been reported as a poor prognostic marker in several tumor types and is associated with poor patient outcomes .
Interventions
None listed
Sponsors
Sohag University
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Inclusion criteria
* Patients with invasive mammary carcinoma carcinoma and underwent surgery
Exclusion criteria
* Cases received pre-operative chemotherapy or radiotherapy. * Cases with insufficient clinical data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| evaluate expression of ALDH1A1 in invasive mammary carcinoma | 4 month | immunohistochemical study |
Countries
Egypt
Outcome results
None listed