Odontogenic Cysts
Conditions
Keywords
Odontogenic cysts, Odontogenic Keratocysts
Brief summary
Background The odontogenic keratocysts (OKCs) have been one of the maxillofacial region's most contentious pathological phenomena. Decompression/marsupialization (D/M), enucleation (E), enucleation + chemical cauterization with Carnoy's solution (E+CS), enucleation + peripheral ostectomy (E + PO), as opposed to enucleation + chemical cauterization with Carnoy's solution + peripheral ostectomy (E + CS + PO), were used during surgery to ensure that no epithelial remnants were left behind. Rationale Through the management of OKC a recurrence could occur, the effectiveness of Decompression/marsupialization (D/M), Enucleation (E), Enucleation+Carnoy's solution chemical cauterization (E+CS), Enucleation+peripheral ostectomy (E+PO), Enucleation+Carnoy's solution chemical cauterization + peripheral ostectomy (E+CS + PO), will be analyzed
Detailed description
Since the middle of the 20th century, the odontogenic keratocyst (OKC) has been one of the maxillofacial region's most contentious pathological phenomena. It was initially misdiagnosed as a primordial cyst. After that, because of its severe clinical behavior and tendency to recur, it was no longer considered to be a part of its classification, also known as a odontogenic tumor. Then, In 2017, the OKC are re-classified as a cystic lesion. But still there is debate about their management. So, this study will be enrolled with the following objectives: to describe how odontogenic keratocysts are managed, to Discover the most favorable approach to manage OKC with the need to stop it from happening again To categorize the odontogenic keratocyst management outcomes into to the subsequent groups: (1) total resolution, (2) partial resolution; (3) Recurrence.
Interventions
PROCEDUREEnucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+CS + PO)
The enucleation procedures, which were meticulously carried out in order to remove the odontogenic keratocyst in one piece without breaking its lining or leaving any epithelial remnants.The peripheral ostectomy treatment will be carried out with a large spherical bur and plenty of irrigation.After filling the bone cavity with more sterile gauze, the Carnoy's solution was slowly injected into it with a plastic syringe. The gauze was continuously injected with CS until it was fully saturated without leaking too much into the surrounding tissues. The CS was held in place for 3 minutes.
PROCEDUREDecompression/ marsupialization (D/M)
A surgical window will be created in the cyst wall to drain the contents while retaining continuity between the cyst and the oral cavity
PROCEDUREEnucleation (E)
The enucleation will be accomplished in the same manner that it will be performed in the group of Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+ PO+ CS).
PROCEDUREEnucleation+Carnoy's solution (E+CS)
Both enucleation and Carnoy's solution will be carried out as planned in the group Enucleation+ Peripheral Ostectomy+Carnoy's solution chemical cauterization (E+ PO+ CS).
PROCEDUREEnucleation+ Peripheral Ostectomy (E+ PO)
Both enucleation and peripheral ostectomy will be carried out as planned in the group Enucleation+ Peripheral Ostectomy+ Carnoy's solution chemical cauterization (E+ PO+ CS).
Sponsors
Al-Azhar University
Qassim University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
The patients, investigators, and outcomes assessor will not be informed about the study
Intervention model description
The patents will be divided into five groups according to the treatment modalities used to treat their odontogenic cysts
Eligibility
Sex/Gender
ALL
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All odontogenic keratocysts that are treated by the following surgical treatment modalities: 1. Enucleation followed by peripheral ostectomy and Carnoy's solution 2. Decompression/ marsupialization 3. Enucleation 4. Enucleation and Carnoy's solution 5. Enucleation and Peripheral Ostectomy * Follow-up period 10 years
Exclusion criteria
* Cases treated with resection * Cases showed neoplastic transformation in their pathology * Cyst Like lesions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Healing period | Starting from the postoperative third month up to the postoperative ninth month | The bone filling will monitored by using computed tomography scans |
| Measurement of the bony cavity | At the end of the postoperative ninth month | A presence of radiolucent area in the computed tomography scans |
| Recurrence rate | At the end of the postoperative fifth year | The new occurrence of the previously removed odontogenic keratocyst will be documented |
Countries
Saudi Arabia
Outcome results
None listed