Non Communicable Diseases, Microbiome, Communicable Diseases, Pesticide Exposure, Metal Poison, Genetics Population, Ciguatera
Conditions
Keywords
cross-sectional survey, non-communicable disease, communicable disease, French Polynesia, population genetics
Brief summary
This is a cross-sectional study carried out on a sample of the adult population aged 18 to 69, distributed over the five archipelagos of French Polynesia. Participation in the study involves: agreement to answer a questionnaire to collect information on socio-demographic characteristics, lifestyle habits and medical history; physical measurements (height, weight, waist circumference, blood pressure and skin pigmentation); and agreement to take biological samples (blood, saliva and stool) for biological, genetic and microbiological analyses. The aim of the study is to assess the current health status of the population of French Polynesia and to evaluate the influence of contextual risk factors (lifestyle, place of residence, history of infection) and intrinsic susceptibility factors (genetics, age, gender, microbiota) in relation to non-communicable and infectious diseases.
Interventions
OTHERQuestionnaire
Questionnaire about socio-demographical status, health status and lifestyle habits
Measurement of height, weight, waist circumference, blood pressure and skin pigmentation
OTHERBiological samples
Collect venous blood, saliva and stool samples
Sponsors
Institut Pasteur
Institut de la Statistique de la Polynésie française
Centre Hospitalier de la Polynésie française
Université de la Polynésie française
Institut National en Santé Publique du Québec
Institut Louis Malardé
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* be aged 18 or over and under 70 on the date of recruitment * having signed the consent form
Exclusion criteria
* Minors * Pregnant or parturient women, and nursing mothers * Persons deprived of their liberty by a judicial or administrative decision * Adults who are the subject of a legal protection measure or who are unable to express their consent * People undergoing psychiatric care * Individuals who are not affiliated to a social security scheme or beneficiaries of such a scheme * Homeless people * Disabled people (unable to move) * People unable to answer the questionnaire
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of obesity | 2 years | Proportion of participants with indicators of obesity based on physical measurements (BMI, waist circumference) and quantification of lipid levels from blood samples. |
| Prevalence of diabetes | 2 years | Proportion of participants with indicators of diabetes based on self-reported data on diabetes history (previous diagnosis, antidiabetic treatment) and quantification of glycated haemoglobin from blood samples. |
| Prevalence of cardiovascular diseases | 2 years | Proportion of participants with indicators of cardiovascular diseases based on self-reported data on history of hypertension (previous diagnosis, treatment for hypertension), blood pressure measurement, and quantification of lipid levels from blood samples. |
| Association between non-communicable diseases and behavioral factors | 2 years | Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and behavioral factors such as tobacco smoking, alcohol consumption, diet or physical activity data self-reported by the participants in the questionnaire. |
| Association between non-communicable diseases and physical measurements | 2 years | Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and physical measurements such as BMI (based on the BMI formula i.e., weight in kilograms divided by height in meters squared). |
| Association between non-communicable diseases and blood analyses | 2 years | Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and blood analyses (such as glycated haemoglobin and lipid levels). |
| Seroprevalence of communicable diseases | 2 years | Proportion of participants with IgG antibodies, detected in blood samples, specific for different pathogens : arboviruses (four dengue serotypes, Zika, chikungunya), hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…). Proportion of participants with positive filarial antigenemia to assess the prevalence of Bancroftian lymphatic filariasis. |
| Composition of microbiome | 2 years | Bacterial DNA sequencing from stool and saliva samples to assess the gut and oral microbiota profiles and association with lifestyle behavior, diet and susceptibility to communicable and non-communicable diseases. |
| Level of exposure to heavy metals | 2 years | Quantification of levels of heavy metals (including mercury and lead) from blood samples and association with lifestyle behavior and diet. |
| Level of exposure to pesticides | 2 years | Quantification of levels of pesticides (including chlordane and toxaphene) from blood samples and association with lifestyle behavior and diet. |
| Level of exposure to mosquito bites | 2 years | Proportion of participants with IgG antibodies targeting mosquito salivary proteins in blood samples to assess the risk of infection by mosquito-borne viruses |
| Prevalence of ciguatera poisoning | 2 years | Estimation of the rate of ciguatera poisoning in the population based on data self-reported by the participants in the questionnaire e.g. the occurrence of symptoms suggestive for ciguatera poisoning at least once in their lifetime |
| Demographic and adaptive history of French Polynesians using genomics | 2 years | Human Whole Genome Sequencing from saliva samples to reconstruct the genetic history of the population of French Polynesia, in terms of both demographic and adaptive history. |
| Genetic susceptibility to obesity | 2 years | Genome-wide association studies to identify human genetic factors that are associated with BMI or lipids levels. |
| Genetic susceptibility to diabetes | 2 years | Genome-wide association studies to identify human genetic factors that are associated with HbA1c. |
| Genetic susceptibility to communicable diseases | 2 years | Genome-wide association studies to identify human genetic factors that are associated with the detection of IgG antibodies specific for different pathogens: arboviruses, hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…). |
Countries
French Polynesia
Outcome results
None listed