Systemic Sclerosis
Conditions
Brief summary
Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation. An important cause of impaired hand function are contractures of the hand, which are reported in up to a half of patients. With this longitudinal cohort study in patients with SSc and VEDOSS (very early diagnosis of systemic sclerosis) the investigators aim to gain more insight into processes involved in hand function impairment.
Interventions
DIAGNOSTIC_TESTImaging, blood samples, fuctional tests and physical examination
Imaging, blood samples, fuctional tests and physical examination
Sponsors
University Medical Center Groningen
Radboud University Medical Center
Leiden University Medical Center
Royal Free Hospital NHS Foundation Trust
UMC Utrecht
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years
Exclusion criteria
* Patients with diabetic cheiroarthropathy and Dupuytren's disease, based on expert opinion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of risk factors for hand function impairment in systemic sclerosis (SSc) patients with early disease, very early disease and established hand impairment (contractures) at 2 years follow-up | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Identify underlying mechanisms | 2 years |
| - Validation of the Dutch PASTUL questionnaire | 2 years |
Countries
Netherlands
Outcome results
None listed