Cirrhosis
Conditions
Keywords
Frailty markers, Quadriceps strength
Brief summary
Physical frailty and malnutrition are important factors in morbidity and mortality in patients with cirrhosis. No study has assessed the validity of Liver Frailty Index (LFI) against reference measures such as maximal lower limb strength. Main objective: To assess the association between LFI score and isometric maximal lower limb strength (quadriceps) in patients with cirrhosis.
Detailed description
Secondary objective: compare the different strength parameters of patients with cirrhosis (strength endurance, rate of strength development) with healthy subjects.
Interventions
OTHERFrailty assessment
Assessments for all patients : isometric quadriceps strength, malnutrition by RFH-NPT and MNA questionnaires, body composition by circumference and triceps skinfold, frailty by LFI and SPPB, muscle cramps by Cramp questionnaire.
OTHERFrailty assessments
Assessments for all healthy volunteers: isometric quadriceps strength, body composition by circumference and triceps skinfold, frailty by LFI and SPPB.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
SUBJECT : * with a diagnosis of liver cirrhosis (regardless of cirrhosis stage and etiology) * under the care of a physician practising in the University Hospital Estaing in Clermont-Ferrand * affiliated to the french social security system
Exclusion criteria
SUBJECT: * with hepatocellular carcinoma * with HIV infection * with hepatic encephalopathy grade ≥ 2 * with cognitive dysfunction * with contraindication for physical activity * with knee pain/knee disorders * pregnant or breastfeeding * under protective supervision (guardianship, curatorship, protection of the court) Inclusion Criteria for healthy volonteers: * male subjects aged 52 to 62 * female subjects aged 42 to 60 * BMI between 20 and 30 kg/m2 * no musculoskeletal problems limiting physical activity * level of physical activity \< 3 hours per week * affiliated to the french social security system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Isometric quadriceps strength | once, at inclusion | Isometric quadriceps strength (N.m) will be assessed 3 times with 30 second rest between each try. The dominant leg of each participant will be assessed, a standardised warm-up will be conducted to have effective results. |
Secondary
| Measure | Time frame |
|---|---|
| Malnutrition: Mini Nutritional Assessment (MNA)) | once, at inclusion |
| Body composition by circumference and triceps skinfold | once, at inclusion |
| Malnutrition: Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) | once, at inclusion |
| Frailty by Short Physical Performance Battery (SPPB) | once, at inclusion |
| Muscle cramps by Cramp questionnaire | once, at inclusion |
| Frailty by LFI | once, at inclusion |
Countries
France
Contacts
Primary ContactLise LACLAUTRE
Outcome results
None listed