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Medical Thoracoscopy in Treatment Outcomes of Empyema Management

Medical Thoracoscopy Versus Conventional Intercostal Tube in Treatment Outcomes of Empyema Management

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06132997
Enrollment
100
Registered
2023-11-15
Start date
2023-12-24
Completion date
2025-03-24
Last updated
2023-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Empyema

Brief summary

To evaluate the efficacy of drainage achieved by thoracoscopy vs tube drainage alone. To compare clinical outcomes such as length of hospital stay, need for additional procedures, and treatment failure rates between the two drainage methods. To asses resolution of pleural infection and rates of fluid re-accumulation over follow-up. To compare safety profiles and complication rates of thoracoscopy versus tube drainage alone

Detailed description

Empyema is a serious infection characterized by pus accumulation in the pleural space. Effective drainage and treatment is necessary for resolution. Traditionally, intercostal tube placement was standard initial management. However, recent studies have compared outcomes of early medical thoracoscopy or video-assisted thoracoscopic surgery (VATS). Thoracoscopy enables direct visualization for thorough pleural space cleansing and debridement under direct vision. medical thoracoscopy significantly improved drainage adequacy and reduced treatment failure risks compared to tube drainage alone. Also reported shorter hospital stays and lower complication rates with early thoracoscopy-directed management. Additional benefits of thoracoscopy include enabling talc pleurodesis for reducing empyema recurrence. thoracoscopy-directed pleurodesis achieved higher long-term success rates than tube drainage followed by pleurodesis. Overall, current evidence indicates medical thoracoscopy provides superior empyema treatment outcomes to conventional tube drainage through optimized drainage and debridement under direct visualization.

Interventions

PROCEDUREThoracoscopy procedure

is a minimally invasive endoscopic procedure utilized by pulmonologists to evaluate, diagnose, and treat pleural pathologies of the lung, mainly pleural effusions.

PROCEDUREChest tube thoracostomy

Insert chest intercostal tube without thoracoscopy

Sponsors

Hend Mohamed Sayed Mohamed
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Masking description

Intercostal chest tube group

Intervention model description

Medical thoracoscopy group

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Confirmed diagnosis of empyema via Imaging tests (e.g. chest x-ray/CT scan) * Age 18 years or older * Clinical signs/symptoms consistent with Empyema such as fever, chest pain, coughs * Pleural fluid loculations/septations seen on Imaging requiring drainage * No previous drainage procedures done for Current empyema

Exclusion criteria

* Age less than 18 years * Immunocompromised state or other conditions Contraindications to thoracoscopy * Previous drainage procedure for current Empyema * Residual pleural fluid not amenable to drain

Design outcomes

Primary

MeasureTime frameDescription
Treatment success:baselineAsses by chest ultrasound

Secondary

MeasureTime frameDescription
Success of pleurodesisbaselinemeasured by assessing the recurrence rate of pleural effusion over a specified follow-up period.

Contacts

Primary ContactHend saleh, MD
hend.m.saleh@gmail.com01098988712
Backup ContactMohamed yassen, MD
Mfawzy2013@hotmail.com0100680052

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026