Exercise CMR in (p)LF-LG AS

Exercise CMR in (Paradoxical) Low-flow Low-gradient Aortic Stenosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06129799

Enrollment

100

Registered

2023-11-13

Start date

2023-11-01

Completion date

2026-12-31

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Stenosis, Severe

Brief summary

Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* paradoxical or conventional severe low-flow low-gradient aortic stenosis

Exclusion criteria

* CMR incapable device * unable to undergo 40 min scan (can not lie flat, claustrophobia) * renal insufficiency (eGFR \<30 ml/min/1.73m²) * allergy against contrast agent * unable to exercise in supine position

Design outcomes

Primary

Measure	Time frame
Composite of events: number of participants with cardiovascular death or heart failure hospitalisation	12 months

Countries

Germany

Outcome results