The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

The Effect of a Novel Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis When Compared to Whey Protein in Healthy Young Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06129513

Enrollment

Registered

2023-11-13

Start date

2022-02-24

Completion date

2022-10-31

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Metabolism

Keywords

Myofibrillar Protein Synthesis, Resistance Exercise, Plant Protein, Stable Isotopes

Brief summary

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Interventions

BEHAVIORALBilateral resistance exercise

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

DIETARY_SUPPLEMENTWhey protein

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

DIETARY_SUPPLEMENTPlant-blend protein

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI between 18 - 30 * Resistance trained (\>3 times per week structured resistance exercise training for at least 3 months)

Exclusion criteria

* Any metabolic impairment * Any cardiovascular impairment * Smoking * Lactose intolerance * Allergies to products containing dairy, meat or nuts * Prescribed intake of over the counter pharmaceuticals

Design outcomes

Primary

Measure	Time frame	Description
Post-exercise myofibrillar protein synthesis following protein ingestion	4 hours	The fractional synthetic rate of myofibrillar proteins

Secondary

Measure	Time frame	Description
Post-exercise myofibrillar protein synthesis during the early postprandial period	2 hours	The fractional synthetic rate of myofibrillar proteins
Post-exercise myofibrillar protein synthesis during the late postprandial period	2 hours	The fractional synthetic rate of myofibrillar proteins
Plasma amino acid response	4 hours	Post-exercise and postprandial change in plasma amino acid concentrations and availability
Serum insulin response	4 hours	Post-exercise and postprandial change in serum insulin concentrations

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026