Stroke
Conditions
Keywords
Dual-task training, Cognitive-motor interference
Brief summary
To assess the effects of a dual-task exercise program on cognitive-motor interference during dual-task walking and the associated changes in brain activity.
Detailed description
Stroke is one of the leading causes of chronic disability in Hong Kong and other parts of the world. Mobility dysfunctions are among the most common impairments observed after stroke. Restoration of mobility is also a top priority in rehabilitation goal-setting by stroke patients. In daily life, functional ambulation in the community requires the ability to maintain walking balance while simultaneously engaging in other attention-demanding tasks (i.e., dual-tasking), such as walking when holding a conversation, or crossing the street while attending to traffic signals. There is increasing evidence that performing a cognitive task in conjunction with a mobility task would cause more severe degradation of one or both tasks among stroke patients when compared with age-matched able-bodied individuals. This phenomenon, termed "cognitive-motor interference", should warrant detailed study, since it has an important impact on community-living among people with stroke.
Interventions
BEHAVIORALDual-task training
This group will receive 30 min of dual-task exercise training and 30 min of stretching exercises in each session. The dual-task component involves walking activities performed in conjunction with cognitive activities. For the stretching exercise component, no cognitive load will be added.
BEHAVIORALSingle-task training
This group will undergo 30 min of single-task mobility training and another 30 min of single-task cognitive activities. The cognitive and mobility exercises will be the same as those in the dual-task group, but they will be performed separately. No extra cognitive load will be imposed during the mobility exercises. No additional motor demand will be imposed during the cognitive exercises, as the participants will be sitting.
BEHAVIORALControl group
This group will undergo 30 min of stretching exercises (same as the dual-task group) and another 30 min of upper limb strengthening exercises performed primarily in the sitting or lying position. No cognitive load will be added.
Sponsors
The Hong Kong Polytechnic University
Research Grants Council, Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
This will be a single-blinded RCT. The assessor will be blinded during assessments. The participants and investigators (trainers) are not possible to be blinded as it is an exercise intervention.
Intervention model description
After stratification according to gender and walking speed, the participants will be randomly allocated to one of three groups: (1) dual-task training, (2) single-task training, and (3) control intervention, using a 1:1:1 allocation ratio.
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of stroke confirmed by brain scan reports * Community-living * Stroke onset ≥ 6 months * Aged 50 years or older * Modified Rankin scale 1-3 * Capable of following verbal instructions * Montreal Cognitive Assessment score ≥ 22 * Ability to walk for 1 min independently with or without a walking aid * Not receiving formal rehabilitation elsewhere
Exclusion criteria
* Other neurological disorders * Pain or other comorbidities that seriously affect the ability to walk * Contraindications to exercise (e.g., angina).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dual-task gait speed | Through study completion, an average of 1 year | Gait speed under dual-task condition will be recorded |
| Dual-task cognitive performance | Through study completion, an average of 1 year | Number of correct responses will be measured during dual-task walking |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dual-task gait performance 1 | Through study completion, an average of 1 year | Gait cadence will be measured during dual-task walking |
| Dual-task gait performance 2 | Through study completion, an average of 1 year | Stride length will be measured during dual-task walking |
| Dual-task gait performance 3 | Through study completion, an average of 1 year | Trunk stability will be measured during dual-task walking |
| Oxyhemoglobin concentration changes of the brain | Through study completion, an average of 1 year | Oxyhemoglobin concentration changes will be measured using functional near infra-red spectroscopy during dual-task walking |
Countries
Hong Kong
Contacts
PRINCIPAL_INVESTIGATORMarco Yiu Chung PANG, PhD
The Hong Kong Polytechnic University
STUDY_DIRECTORXun LI, MSc
The Hong Kong Polytechnic University
Outcome results
None listed