Mediastinal Diseases
Conditions
Brief summary
The goal of this observational study is to learn whether patients undergoing mediastinal disease diagnosis and combined treatment with intrapacial ultrasound-guided mediastinal opening techniques have greater clinical benefit. The main questions it aims to answer are: * Whether the mediastinal ultrasound-guided mediastinal opening technique is more beneficial for the diagnosis of benign or malignant mediastinal diseases. * Does the mediastinal ultrasound-guided mediastinal opening technique benefit the patient by ablating mediastinal masses using freezing, laser, or other means. Mediastinal diseases were diagnosed by lymph node biopsy combined with NGS, ROSE and other techniques using transairway ultrasound-guided mediastinal opening technique. Ablation of mediastinal malignancies is performed using techniques such as freezing or laser. Transbronchial lung biopsy(TBLB) may also be performed when necessary. Researchers will compare the experimental group with mediastinal opening and the control group without mediastinal opening to see if Mediastinal open technique benefits patients.
Interventions
PROCEDUREIntraairway ultrasound-guided mediastinal opening technique
Mediastinal intervention for patients with mediastinal imaging abnormalities is performed under general anesthesia to obtain biopsy specimens for detection or elimination of mediastinal masses
PROCEDURETransbronchial Lung Biopsy (TBLB)
A standardized supplementary procedure performed in all patients with active pulmonary sarcoidosis and fibrosing mediastinitis, regardless of their primary study group assignment, to obtain lung tissue for histopathological diagnosis and disease activity assessment.
Sponsors
Dan Liu
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Radiographic abnormalities of mediastinum * Can tolerate general anesthesia * Can tolerate bronchoscopy and has the condition to have mediastinal biopsy and treatment
Exclusion criteria
* Imaging or other tests can make a definitive diagnosis * Cannot tolerate general anesthesia or tracheoscopic surgery * Patients cannot sign informed consent forms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| In the diagnosis of mediastinal diseases, the difference in diagnosis rate between the experimental group with open mediastinum and the control group with traditional methods was observed | 11 months | The contribution of pathological results to the final diagnosis of the disease between the experimental group and the control group was observed.That is, the difference in diagnostic accuracy between the experimental group and the control group. |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival | 11 months |
| quality of life survey | 11 months |
| number of hospitalizations | 11 months |
| Cost of disease treatment | 11 months |
Countries
China
Outcome results
None listed