Acute Coronary Syndrome
Conditions
Brief summary
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of Heidelberg.
Detailed description
To conduct a comprehensive characterization of patients with symptoms of acute coronary syndrome or elevated troponin levels. Records include clinical routine parameters, there will be an expansion involving the collection of blood samples for the analysis of novel laboratory-based and omics-based biomarkers. The ACS registry is monothetically managed by the Department of Internal Medicine III at Heidelberg University Hospital and is intended to serve as a basis for further clinical diagnostic and outcome studies. The blood samples will serve as the foundation for a comprehensive analysis of established and novel laboratory-based markers, as well as omics-based biomarkers (miRNA, metabolomics, and proteomics). Follow-up was performed via review of medical reports, phone calls and postal queries. The outcome parameters comprised rates for all-cause mortality, non-hemorrhagic stroke, myocardial infarction, and hospitalization for any cause.
Interventions
OTHERno intervention is intended.
no intervention is intended.
Sponsors
University Hospital Heidelberg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
The study will include consecutive patients who present to the cardiology emergency department at Heidelberg University Hospital with symptoms of acute coronary syndrome or a troponin increase (hs-TnT \>14 ng/L). Additional inclusion criteria are a minimum age of 18 years and providing informed consent through written consent to participate in the study. The following medical conditions are intended to be distinguished from one another: * Acute myocardial infarction * Unstable angina pectoris * Myocarditis * Heart failure * Cardiomyopathies * Pulmonary embolism * Renal insufficiency * Supraventricular and ventricular tachycardias * Hypertensive crisis * Non-cardiac chest pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| all-cause mortality | 12 months | all-cause mortality during follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| myocardial infarction | 12 months | myocardial infarction during follow-up |
| stroke | 12 months | stroke during follow-up |
| Rehospitalization | 12 months | Rehospitalization during follow-up |
Countries
Germany
Outcome results
None listed