Periodontitis
Conditions
Keywords
residual pockets, chitosan, treatment of periodontitis
Brief summary
The aim of the current study was to investigate the effect of a chitosan brush on the treatment of residual pockets in patients already treated for periodontal disease. Thirty-six patients with chronic periodontitis (Stage ΙΙΙ, ΙV) that had already completed causative therapy and exhibited at least two residual periodontal pockets ≥ 5mm that bled on probing, were randomly assigned to two groups. In the test group debridement of residual pockets was performed with ultrasonic scaler and the chitosan brush, whereas in the control group only ultrasonic scalers were used.
Interventions
DEVICEchitosan brush
debridement of periodontal pockets with ultrasonic scaler first and after with chitosan brush for 2 minutes
DEVICEultrasonic scaler
debridement of periodontal pockets only with ultrasonic scaler
Sponsors
Aristotle University Of Thessaloniki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Intervention model description
randomized parallel arm clinical trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Subjects aged 18 or over * Subjects diagnosed with chronic periodontitis, Stage III or IV, and had received full mouth scaling and root planning at least three months prior to baseline examination * Subjects with at least two residual periodontal pockets of at least 5mm depth that bled on probing * Full mouth plaques scores ≤20%
Exclusion criteria
* Subjects that had received antibiotic therapy 6 months prior to initial examination * Subjects with compromised systemic conditions * Patients undergoing chemotherapy or radiotherapy * Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing Pocket Depth | baseline, 6 weeks, 3 months, 6 months | the distance from the mucosa margin to the bottom of the periodontal pocket |
| MMP-8 | baseline, 6 weeks, 3 months, 6 months | levels of matrix metalloproteinase -8 in gingival crevicular fluid |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bleeding on Probing | baseline, 6 weeks, 3 months, 6 months | presence or absence of bleeding after probe insertion in the periodontal pocket |
| Clinical Attachment Level | baseline, 6 weeks, 3 months, 6 months | the distance from cementoenamel junction to the bottom of periodontal pocket |
| Gingival Recession | baseline, 6 weeks, 3 months, 6 months | the distance from cementoenamel junction to the mucosa margin |
Countries
Greece
Outcome results
None listed