Eclampsia, Severe Pre-eclampsia
Conditions
Keywords
Pre-eclampsia, Eclampsia, magnesium sulphate
Brief summary
Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria. To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in severe preeclampsia and recurrent fits in eclampsia in a low resource setting. A prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at the Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Sociodemographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted.
Detailed description
Background: Preeclampsia/eclampsia is part of a spectrum of multi-systemic pregnancy disorder that contributes substantially to maternal and perinatal morbidity and mortality, especially in low resource setting. This study was done in Abakaliki, Ebonyi State, Southeast Nigeria. Objectives: To compare the efficacy of loading dose of magnesium sulphate with that of the Pritchard regimen in the prevention of eclampsia in patients with severe preeclampsia and recurrent fits in eclampsia in a low resource setting like ours. Methods: This was a prospective, single blinded randomized controlled study of loading dose versus Pritchard regimens of MgSO4 at Alex Ekwueme Federal University Teaching Hospital Abakaliki. One hundred and twenty patients were recruited 60 to each arm using computer-generated numbers. Social demographic characteristics, efficacy and adverse effects of the drug on the mother and baby were noted. Data were collated, tabulated and analyzed using the statistical package for social sciences (SPSS) software (version 22, Chicago II, USA)
Interventions
DRUGUse of magnesium sulfate to prevent and stop fits in pre-eclampsia and Eclampsia
Loading dose magnesium sulfate versus the Pritchard regimen
Sponsors
Federal Teaching Hospital Abakaliki
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Prevention of Eclampsia in severe pre-eclampsia and further fits in Eclampsia.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 44 Years
Healthy volunteers
No
Inclusion criteria
* Pregnant women with severe preeclampsia * Pregnant women with eclampsia * Signing of informed consented to participate in the study.
Exclusion criteria
* Refusal of consent, * Gestational age \< 28 weeks * Received magnesium sulphate prior to presentation * mild preeclampsia * chronic hypertension in pregnancy * Medical or Obstetrical complication of pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of convulsions | During the intervention | percentage of fits in severe pre-eclampsia and recurrence of fits in eclampsia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Drug toxicity | During the intervention | number of neonatal asphyxia, respiratory depression, loss of tendon reflex and cardiac arrest. |
Countries
Nigeria
Outcome results
None listed