Coronary Microvascular Disease, Coronary Vasospasm
Conditions
Brief summary
The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.
Detailed description
Microvascular dysfunction is an important determinant of patients´quality of life and prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear understanding and diagnosis has a potentially large clinical importance. It is therefore important to better describe the phenotype of these patients. The MICRO-SNAPE registry will allow investigating these associations. Patient data as collected during the local clinical practice and at the operator's discretion, will be retrospectively entered in this non-interventional registry in anonymous form.
Interventions
DIAGNOSTIC_TESTCoronary physiology assessment
Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and papaverin or adenosine, Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and acetylcholine.
Sponsors
Johannes Gutenberg University Mainz
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients who underwent combined measurements of coronary pressure and flow in at least 1 native coronary artery in response to endothelium dependent and independent vasodilators.
Exclusion criteria
* Hemodynamic instability * Age \<18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of endotypes of coronary vasomotor function | immediately after the invasive measurement | Patients will be classified in different endotypes according to the pattern of their responses to endothelium-dependent and independent vasodilators. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Normal values expressing endothelium-dependent coronary flow reserve | immediately after the invasive measurement | Acetylcholine-induced coronary flow reserve in subjects without microvascular dysfunction. |
| Sex impact on coronary vasospasm measures | immediately after the invasive measurement | Difference between males and females in microvascular and epicardial spasm measures |
| Accuracy of clinical criteria for the diagnosis of microvascular and epicardial spasm | immediately after the invasive measurement | The clinical criteria commonly used for the diagnosis of spasm (based on ECG and angina) will be validated against the benchmark invasive measurements |
| Acetylcholine versus adenosine responses | immediately after the invasive measurement | Comparison of adenosine- versus acetylcholin-induced microvascular dilatation (IMR) |
| Normal values and associations of resting microvascular resistances | Immediately upon measurment | We will assess the normal values of resting microvascular resistances using a frequentistic approach and study their associations with comorbidities and clinical parameters. |
| Coronary bridge and epicardial spasm | immediately after the invasive measurement | Impact of coronary brudge on the incidence of epicaridal spasm |
Countries
Germany
Outcome results
None listed