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Improved Pain Management in Knee Osteoarthritis-related Surgeries

Evaluating the Effectiveness of Continuously Improved Pain Management in Knee Osteoarthritis-related Surgeries

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06124170
Enrollment
714
Registered
2023-11-09
Start date
2016-03-01
Completion date
2023-03-02
Last updated
2023-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Tibial Osteotomy, Knee Osteoarthritis, Pain Management, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty

Brief summary

In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

Detailed description

We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Interventions

PROCEDUREPreoperative pain managment

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

PROCEDUREIntraoperative pain managment

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

PROCEDUREPostoperative pain managment

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Sponsors

Peng Liu
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* first knee surgery were 50-80 years old had complete clinical and follow-up data

Exclusion criteria

* American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration

Design outcomes

Primary

MeasureTime frameDescription
visual analogue score (VAS)24 hours after surgeryvisual analogue score (VAS)

Secondary

MeasureTime frameDescription
Quadriceps muscle strength24 hours after surgeryQuadriceps muscle strength
Scope of activities to knee joint24 hours after surgeryScope of activities to knee joint

Other

MeasureTime frameDescription
Self-Rating Anxiety Scale (SAS)24 hours after surgerySelf-Rating Anxiety Scale (SAS)
Self-Rating Depression Scale (SDS)24 hours after surgerySelf-Rating Depression Scale (SDS)

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026