Desflurane and Sevoflurane on Remifentanil Requirement

Comparison of Desflurane and Sevoflurane on Remifentanil Requirement Using Analgesia Nociception Index-guided Anesthesia

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06123624

Enrollment

Registered

2023-11-09

Start date

2023-11-27

Completion date

2024-08-30

Last updated

2023-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Diseases

Brief summary

The primary purpose of this study is to compare the desflurane and sevoflurane on remifentanil requirement using analgesia nociception index-guided anesthesia in patients undergoing spine surgery.

Interventions

DRUGDesflurane Inhalation Solution

Keeping the anesthesia using desflurane inhalation solution as 1 minimal alveolar concentration

DRUGSevoflurane Inhalation Solution

Keeping the anesthesia using sevoflurane inhalation solution as 1 minimal alveolar concentration

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

19 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of herniated disc, injury of spinal cord, and neoplasm of spinal meninges

Exclusion criteria

* Hyperbilirubinemia * Prior chronic pain * Prior opioid abuse * Cardiac arrythmia

Design outcomes

Primary

Measure	Time frame	Description
remifentanil requirement	at time of the end of skin suture (up to 3 hours)	assessing the total dose of remifentanil administered from skin incision until skin suture

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026