Dry Eye, Dry Eye Disease
Conditions
Brief summary
Strip meniscometry is a relatively new method for evaluating the tear meniscus. The aim of the study is to evaluate the possible effect of cataract surgery on ocular surface disease and to assess the possible benefit of strip meniscometry in the preoperative and postoperative evaluation of patients.
Detailed description
Cataract surgery is one of the most successful anterior segment surgeries and usually results in excellent postoperative visual acuity. However, some patients may experience symptoms of dry eye disease after a successful procedure, most commonly a foreign body sensation in the eye, intermittent pain, and blurred vision. These problems then interfere with normal daily activities and also reduce the patient's satisfaction with the surgery. The new method for tear film examination Strip meniscometry (SM) appears to be a suitable alternative to the Schirmer test. SM values correlate with Oxford score (fluorescein staining), tear break up time test or measurement of meniscus height using anterior segment optical coherence tomography. It is a minimally invasive and rapid examination method that measures the volume of the aqueous component of the tear film. The aim of this study is to evaluate the possible influence of cataract surgery on the development of iatrogenic OSD and to assess the contribution of a new diagnostic method, SM, for the evaluation of OSD before and after cataract surgery.
Interventions
DIAGNOSTIC_TESTCentral visual acuity
Measurement of central visual acuity using Snellen optotype chart.
DIAGNOSTIC_TESTIntraocular pressure measurement
Measurement of intraocular pressure using non-contact Canon TX-20P tonometer.
DIAGNOSTIC_TESTSlit lamp examination
Slit lamp examination of the anterior and posterior segment of the eye after pharmacological dilation of the pupil using application of short-time mydriatics (1% tropicamide and 10% phenylephrine).
DIAGNOSTIC_TESTRefraction and keratometry
Measurement of refraction and keratometry using refractometer Nidek ARK-1a.
DIAGNOSTIC_TESTOptical biometry
Measurement of optical biometry using biometer Argos (Barrett or SRK/T formula).
DIAGNOSTIC_TESTStrip meniscometry (SM)
Strip meniscometry examination using strip meniscometry tube.
DIAGNOSTIC_TESTLid Parallel Conjunctival Folds test (LIPCOF)
Evaluation of lid parallel conjunctival folds using slit lamp examination.
DIAGNOSTIC_TESTStaining of the ocular surface with fluorescein
Evaluation of ocular surface fluorescein staining using Oxford scheme.
DIAGNOSTIC_TESTTear break up time test (TBUT)
Evaluation of tear break up time using slit lamp examination.
OTHEROcular Surface Disease Index questionnaire (OSDI)
Evaluation of Ocular Surface Disease Index using Ocular Surface Disease Index questionnaire.
Sponsors
Palacky University
University Hospital Olomouc
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age over 18 years * performing of pre-operative examination before cataract surgery * signed informed consent
Exclusion criteria
* use of antiglaucoma drugs * chronic blepharitis * previous viral keratitis * previous keratoplasty or laser refractive surgery * known systemic disease causing changes on ocular surface (diabetes mellitus, connective tissue disease) * use of medication causing changes on ocular surface (antidepressant, beta blockers)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in strip meniscometry. | Week 1, 4, 12 | Strip Meniscometry Tube in millimeters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in tear film stability. | Week 1, 4, 12 | Tear break up time test in seconds. |
| Change in ocular surface fluorescein staining. | Week 1, 4, 12 | Oxford scheme grading with range from 0 (none staining dots) to 5 (severe dry eye). |
| Change in lid-parallel conjunctival folds evaluation. | Week 1, 4, 12 | Lid-parallel conjunctival folds (LIPCOF) grading from 0 (no conjunctival folds) to 3 (more than two permanent and clear parallel folds (normally higher than 0.2 mm). |
| Change in Ocular Surface Disease Index. | Week 1, 4, 12 | Ocular Surface Disease Index (OSDI) questionnaire with range from 0 to 100 (higher score represents greater disability). |
Countries
Czechia
Outcome results
None listed