Atrial Fibrillation, Hyperuricemia
Conditions
Keywords
hyperuricemia, atrial fibrillation
Brief summary
To clarify the predictive effects of uric acid and superoxide dismutase as biomarkers of oxidative stress on atrial fibrillation, and to provide greater value for the diagnosis and prediction of atrial fibrillation. It provides a new idea for the prevention and treatment of atrial fibrillation.
Detailed description
In recent years, a growing number of reports have shown the importance of oxidative stress in the pathophysiological mechanism of AF. During oxidative stress, there is an imbalance between the production of pro-oxidant reactive species and the antioxidant defenses of the cell, and excessive oxidation leads to oxidative damage and cell death. Redox processes can lead to atrial fibrosis and cardiac remodeling , suggesting that strategies to address myocardial oxidative stress may constitute a reasonable approach for the treatment of AF. However, few studies have reported the relationship between comprehensive oxidative stress-related biomarkers and AF. The purpose of this study was to illuminate the relationship of several blood markers of oxidative stress with AF and to provide new clues for the prevention and treatment of AF.
Interventions
DIAGNOSTIC_TESTatrial fibrillation
ECG of atrial fibrillation last more than 30 seconds.
Sponsors
Yinglong Hou
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
This retrospective study enrolled all hospitalized patients from January 2018 to December 2020 at the Department of Cardiology in The First Affiliated Hospital of Shandong First Medical University. The diagnosis of AF was based on 12-lead electrocardiography (ECG) or 24-hour Holter monitoring, and classification was based on the published 2020 ESC guidelines for the diagnosis and management of AF.
Exclusion criteria
1. acute heart failure and acute myocardial infarction; 2. severe liver or kidney dysfunction (with aspartate aminotransferase or alanine aminotransferase levels three times higher than normal and estimated glomerular filtration rate \<30 ml/ (min\*1.73 m2)); 3. malignant tumors; 4. missing data of laboratory indicators at baseline.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uric acid/SOD ratio is associated with atrial fibrillation | 3 years | Uric acid/SOD ratio is associated with atrial fibrillation |
Countries
China
Contacts
Primary ContactYinglong Hou, PhD
Outcome results
None listed