Anesthetic Efficacy of 1.8 ml Versus 3.6 ml of 4% Articaine Buccal Infiltration

Anesthetic Efficacy of 1.8 ml Compared to 3.6 ml of Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06119139

Enrollment

Registered

2023-11-07

Start date

2023-12-31

Completion date

2025-06-30

Last updated

2023-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic Irreversible Pulpitis

Brief summary

The aim of the study is to compare the anesthetic efficacy and need for supplemental anesthesia of 1.8 ml compared to 3.6 ml of 4% articaine buccal infiltration in mandibular molars with symptomatic irreversible pulpitis.

Detailed description

Patients with moderate-to-severe pain due to symptomatic irreversible pulpitis will be included. Patients will be randomly assigned into two groups to receive either 1.8 ml 4% articaine buccal infiltration or 3.6. ml 4% articaine buccal infiltration before single visit root canal treatments. Intraoperative pain will be assessed using an 11-point numerical rating scale (NRS) so that anesthetic success will be defined as no to mild intraoperative pain. The need for supplemental anesthesia will also be recorded.

Interventions

DRUG3.6 ml 4% Articaine hydrochloride

3.6 ml 4% articaine buccal infiltration

DRUG1.8 ml 4% Articaine hydrochloride

1.8 ml 4% articaine buccal infiltration

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

Parallel, randomized, clinical trial

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

1. Healthy patients who are categorized as I or II according to The American Society of Anesthesiologists (ASA class I or II). 2. No sex predilection 3. Patients with symptomatic irreversible pulpitis 4. Patient with the ability to understand and use pain scales. 5. Patients who accept to enroll in the study.

Exclusion criteria

1. Patients' allergies to any of the drugs or materials used in the study. 2. Pregnant and lactating females. 3. Patients taking analgesics in the last 6-8 hours. 4. Patients having more than one symptomatic tooth in the same quadrant

Design outcomes

Primary

Measure	Time frame	Description
Anesthetic success	During the procedure	Will be measured by 11-point numerical rating scale NRS. The success will be defined as no or mild pain (NRS 0 or less than 3) and the failure will be defined as moderate to severe pain (NRS more than 3).

Secondary

Measure	Time frame	Description
Need for supplemental anesthesia	During the procedure	Whether the patient requires supplemental anesthesia or not. It will be recorded by the questionnaire (yes or no).

Contacts

Primary ContactHebatullah Moheb Ibrahim

heba.eid@dentistry.cu.edu.eg00201114563058

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026