Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors

Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors: a Prospective, Multicenter Cross-sectional Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06118437

Enrollment

1550

Registered

2023-11-07

Start date

2023-07-15

Completion date

2025-07-31

Last updated

2025-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Tumor of Digestive Tract, Risk Factors

Brief summary

Gastrointestinal tumors (esophageal cancer, gastric cancer, colorectal cancer) seriously threaten human health, with a high incidence rate and cancer related hope mortality. Digestive endoscopy is the main method for screening gastrointestinal tumors. Early screening of gastrointestinal tumors can improve the detection of early cancer and improve prognosis. The five-year survival rate of early stage tumors after comprehensive treatment can reach 90%, while the five-year survival rate of late stage tumors is less than 30%. Therefore, the screening of gastrointestinal tumors is very important. Studies have shown that there are similarities in risk factors for gastrointestinal tumors, such as age, gender, family history, smoking, alcohol consumption, etc. Currently, established digestive malignancies are targeted at a single malignant tumor. At present, there is a lack of understanding of the overall risk factors associated with gastrointestinal tumors and the establishment of relevant risk prediction models. Therefore, we conducted a prospective, multicenter cross-sectional study to explore the independent risk factors of combined gastrointestinal tumors and establish a risk prediction model for combined screening of gastrointestinal tumors.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Individuals aged 18-80; * Undergoing both gastroscopy and colonoscopy simultaneously.

Exclusion criteria

* History of esophageal, gastric, or colorectal cancer; * Suspicions of gastrointestinal obstruction or perforation; * History of gastrointestinal tract surgery; * Not suitable for endoscopic examination due to serious diseases or unstable hemodynamics; * Unavailable relevant information; * Pregnancy or lactation period; * Unavailable informed consent form.

Design outcomes

Primary

Measure	Time frame	Description
Overall detection rate of gastrointestinal cancer	2 years	The proportion of at least one type of gastrointestinal malignant tumor detected

Countries

China

Contacts

Primary ContactYang lin Pan, MD

yanglinpan@hotmail.com862984771536

Outcome results