Shanghai Ovarian Cancer and Family Care Project

Conditions

Ovarian Cancer

Brief summary

Ovarian cancer is the most lethal gynaecological malignancy, but its incidence in the general population is low. Due to the lack of effective prevention and successful screening approaches, most cases are diagnosed at advanced stages, leading to poor prognosis. In order to address the research requirements pertaining to ovarian cancer, the Shanghai Ovarian Cancer and Family Care Project was established. This initiative offers hospital-based resources for investigating ovarian cancer and high-risk populations. The project comprises an on-going ovarian cancer cohort, a high-risk population cohort, and a healthy population cohort. By leveraging these comprehensive cohorts, the project provides a unique platform for in-depth studies on the detection, prevention, early diagnosis, treatment, and prognosis of ovarian cancer.

Rui Bi, Yue Zhang, Wenpei Shi, Huijuan Yang, Shanshan Cheng et al. (14 authors)

Journal of Clinical Oncology2025-05-28

10.1200/jco.2025.43.16_suppl.5546

Protocol of the SOCFC project: a longitudinal cohort study of ovarian cancer patients, high-risk populations, and healthy controls to identify factors and biomarkers associated with disease diagnosis and prognosis

Wenpei Shi, Yue Zhang, Shanshan Cheng, Yaqian Zhao, Na Li et al. (10 authors)

BMC Cancer2025-02-261 citations

10.1186/s12885-025-13652-9

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Participant meet the criteria for one of the following conditions: * Patients attending the oncology department require differential diagnosis of ovarian cancer. * Patients with known high-risk factors for ovarian cancer, such as history of ovarian cancer or BRCA-associated cancer, etc. * Patients attending the Physical Examination Center who have normal findings on physical examination and no symptoms.

Exclusion criteria

* Individuals with evidence of another active cancer. * Individuals who have prior bilateral oophorectomy. * Individuals who are unwilling or unable to sign the informed consent form.

Design outcomes

Primary

Measure	Time frame	Description
Death due to ovarian cancer	From diagnosis of ovarian cancer until October 31, 2028.	Death due to ovarian cancer determined by independent outcomes committee.

Countries

China

Contacts

Primary ContactYu Wang, MD; PhD

renjiwangyu@126.com20261208

Outcome results