The North Kynouria Project

Mass Screening of the Population of the North Kynouria Municipality in Arcadia, Greece for the Detection of Cardiovascular and Stroke Risk Factors

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06115213

Enrollment

7000

Registered

2023-11-02

Start date

2022-11-01

Completion date

2025-11-30

Last updated

2023-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Cerebrovascular Disease, Coronary Disease, Diabetes Mellitus, Dyslipidemias, Heart Diseases, Hypertension, Myocardial Infarction, Peripheral Artery Disease, Stroke (CVA) or TIA

Keywords

Atherosclerosis, Vascular Disease, Arterial Occlusive Diseases

Brief summary

The North Kynouria Project was initiated to study cardiovascular/stroke risk factors by employing mass screening and long-term surveillance of an adult population in the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The North Kynouria Study was initiated to assess modifiable and non-modifiable determinants of cerebrovascular and coronary heart disease.

Detailed description

BACKGROUND: The North Kynouria Project is a longitudinal, interventional-behavioural, prospective study aiming to identify cardiovascular/stroke risk factors, in the adult population of the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The project, initiated in November 2022, recruits volunteers, of both sexes, over 18 years of age, irrespective of their personal history of cardiovascular disease. The epidemiology and burden of cardiovascular disease in North Kynouria remain unknown. The study aims to explore and document the prevalence of major cardiovascular/stroke risk factors, as well as the nutritional status, cigarette smoking, exercise habits, alcohol consumption, and overall quality of life of the inhabitants. DESIGN NARRATIVE: The screening exam is conducted at the Astros, Health Center, by obtaining the patient's personal history, and information about the patient's habits, such as physical activity, smoking, and alcohol consumption. Body weight, height, and waist-to-hip ratio are also measured. During the examination, blood pressure is evaluated using a pre-specified protocol, including assessment of orthostatic hypertension. Further testing includes electrocardiography, ankle-brachial index, direct ophthalmoscopy, and carotid and cardiac ultrasound. Blood samples are collected and stored at the deep freeze of the Astros premises, and blood count, lipid panel, and liver and kidney function are measured. The main field of interest is the prevalence and burden of risk factors and cardiovascular disease in the wider region of North Kynouria, Arcadia Greece. The project aims to assess the epidemiology of CVD and consequently improve public health and engage with the local community through healthy behavioral education.

Interventions

BEHAVIORALPatient counselling

Patient counseling, lifestyle modifications, medication evaluation, and adherence

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Yes

Inclusion criteria

* residents of North Kynouria

Exclusion criteria

* under 18, * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Major adverse cardiovascular events	up to 5 years after enrollment	myocardial infarction, ischemic and hemorrhagic stroke
All-cause mortality	up to 5 years after enrollment	Death by any cause, cardiovascular, infection, cancer, other
Hospitalizations	up to 5 years after enrollment	Any cause hospitalization
Emergency room visits	up to 5 years after enrollment	Any cause of emergency room visit

Secondary

Measure	Time frame	Description
New diagnosis of dyslipidemia	up to 1 year after enrollment	New diagnosis or uncontrolled
New diagnosis of peripheral artery disease	up to 1 year after enrollment	Ankle Brachial Index evaluation
New diagnosis of carotid atherosclerosis	up to 1 year after enrollment	Evaluation of carotid artery stenosis
New diagnosis of diabetes mellitus	up to 1 year after enrollment	Type 1 or Type 2
New diagnosis of Arterial hypertension	up to 1 year after enrollment	Any diagnosis of arterial hypertension, masked, white-coat, nocturnal

Countries

Greece

Contacts

Primary ContactCharalampos Milionis, MD, PhD

hmilioni@uoi.gr

Backup ContactGeorge Ntaios, MD, PhD

gntaios@med.uth.gr6972770288

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026