Cognitive Function
Conditions
Keywords
neurotrophic growth factors, IGF-1, BDNF, VEGF, Irisin, Hcy
Brief summary
The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are: 1. Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy. 2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete. Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets). Researchers will compare the training effects of two different training on these growth factors.
Interventions
The HIRT protocol comprised five exercises (bench press, barbell back squat, deadlift, seated leg flexion, and reverse arm curl) at 80% of 1RM, and 4-5 sets of 12 repetitions with 1-2 minutes of rest period between sets for approximately 60 minutes.
For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.
Sponsors
Air Force Military Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* age between 18 to 30 years * no experiencing musculoskeletal disorders or sports injuries * had not participated any regular aerobic endurance or resistance training with in the previous half years * no smoking habit or intake alcohol and other medication (e.g., steroid hormone) * good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis)
Exclusion criteria
* experiencing musculoskeletal disorders or sports injuries in recent 1 month * had regular resistance training exercise * intake any supplementary(drug and hormone)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rata of perceived exertion | 0 minutes 60 minutes 90 minutes | The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period. |
| Irisin | 0 minutes 60 minutes 90 minutes | regulators of neurogenesis |
| Hcy | 0 minutes 60 minutes 90 minutes | homocysteine (Hcy) increase with age and resulted in cognitive function decline through greater oxidative stress and vascular dysfunction |
| Blood lactate | 0 minutes 60 minutes 90 minutes | serum blood lactate |
| BDNF | 0 minutes 60 minutes 90 minutes | regulators of neurogenesis |
| IGF-1 | 0 minutes 60 minutes 90 minutes | regulators of neurogenesis |
| VEGF | 0 minutes 60 minutes 90 minutes | regulators of neurogenesis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy rate | 0 minutes 60 minutes 90 minutes | Accuracy refers to the correct degree of expression or description of a thing, which is used to reflect the correct answer to the thing |
| Reactive time | 0 minutes 60 minutes 90 minutes | Reaction time is the time it takes for the body to go from receiving a stimulus to responding to an action |
Contacts
Primary ContactChongwen Zuo, Doctoral
Outcome results
None listed