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Comparison of Pre-operative EUS Guided and Intra-operative Direct Portal Vein Pressure Measurement in Pretransplant Cirrhotics

Comparison of Pre-operative EUS Guided and Intra-operative Direct Portal Vein Pressure Measurement in Pretransplant Cirrhotics - Prospective Observational Study

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06114355
Enrollment
25
Registered
2023-11-02
Start date
2023-12-01
Completion date
2024-12-01
Last updated
2023-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis

Brief summary

Direct portal pressure measurement under EUS-guidance (EUS-PPM) is a promising alternative to conventional indirect Hepatic Venous Pressure Gradient (HVPG). In patients undergoing liver transplantation for cirrhosis, high pre-operative portal vein (PV) pressure requires intra-operative portal vein inflow modulation (PIM). This pilot study aims to assess correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Interventions

PROCEDUREEUS Portal pressure measurement

Direct portal pressure measurement under EUS-guidance (EUS-PPM) is a promising alternative to conventional indirect Hepatic Venous Pressure Gradient (HVPG). In patients undergoing liver transplantation for cirrhosis, high pre-operative portal vein (PV) pressure requires intra-operative portal vein inflow modulation (PIM)

Sponsors

Asian Institute of Gastroenterology, India
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Liver cirrhosis patients scheduled for liver transplant for the standard indications within next 24- 48 hours will be included.

Exclusion criteria

* Severe ascites not amenable for tapping * History of blood thinner consumption within last 5 days * Active duodenal ulcerations

Design outcomes

Primary

MeasureTime frameDescription
Correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).1 yearCorrelation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Secondary

MeasureTime frameDescription
Correlation between readings of EUS-PPM using portable manometry set and arterial transducer.1 yearCorrelation between readings of EUS-PPM using portable manometry set and arterial transducer.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026