Major Depressive Disorder
Conditions
Keywords
Major Depressive Disorder, Acupoint, Biological specificity
Brief summary
Evidence-based medicine suggests that acupuncture can improve major depressive disorder (MDD). However, the prevalent reliance on experiential acupoint selection lacks scientific underpinning. The investigators conducted a comparative study involving MDD patients and healthy subjects, employing modern techniques to discern biological specificity in MDD-related acupoints. Additionally, the investigators investigated potential correlations between acupoint biological specificity and MDD severity.
Detailed description
A final total of 134 eligible subjects were included. Among them, 50 healthy subjects were assigned to the healthy control (HC) group and 84 MDD participants were assigned to the MDD group.
Interventions
None listed
Sponsors
Zhejiang Provincial Tongde Hospital
First People's Hospital of Hangzhou
Xiaomei Shao
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria for the healthy control participants: * provided a recent depression screening report, and be free of any cardiovascular, respiratory, digestive, urinary, hematological, endocrine, or neurological disease; * 18 ≤ age ≤60 years, male or female; * had clear consciousness and could communicate with others normally; - understand the full study protocol and have high adherence; * signed the written informed consent. Inclusion criteria for the MDD participants: * consistent with the diagnosis of MDD in the International Classification of Diseases 10th Edition (ICD-10); * 18 ≤ age ≤ 60, male or female; * had clear consciousness and could communicate with others normally; * understand the full study protocol and have high adherence; * signed the written informed consent.
Exclusion criteria
* The
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Temperature | Baseline | Temperature of acupoints was measured by infrared thermography (IRT). IRT was not be performed on female subjects during their menstrual and ovulatory periods. |
| Pressure pain threshold | Baseline | Pressure pain threshold was measured by pressure pain threshold gauge (PTG). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Hamilton Depression Scale-17 (HAMD-17) Scores | Baseline | The HAMD scale is the most commonly used in the clinical assessment of depression, including 17 items. The higher the score, the more severe the depression. 0-6 means no depressive symptoms, 7-16 means mild depression, 17-24 was divided into moderate depression, and more than 25 was divided into severe depression. |
| The Patient Health Questionaire-9 Items (PHQ -9) | Baseline | The PHQ-9 scale has a total of 9 questions, each with a score of 0-3 (none: 0; a few days: 1; more than half of the time: 2; almost every day: 3), with a total score of 0-27. |
| The Self-Rating Depression Scale (SDS) Scores | Baseline | The standard score is the total of all scores multiplied by 1.25 to the nearest whole number on this scale, which has 20 questions. A standard score below 50 is normal; 53-62 is mild depression; 63-72 is moderate depression; 72 or more is severe depression. |
Countries
China
Outcome results
None listed