Acoustic Neuroma, Neurinoma, Acoustic, Vestibular Schwannoma
Conditions
Keywords
vestibular, schwannoma, radiosurgery, gamma-knife, neurinoma, acoustic
Brief summary
The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.
Detailed description
Vestibular schwannoma is a benign tumor located on the vestibulocochlear nerve. It represents 6 to 8% of intracranial tumors, 80% of ponto-cerebral angle tumors and its frequency is 13 cases per million inhabitants per year. The main symptoms related to the development of vestibular schwannoma are unilateral deafness of perception, unilateral tinnitus, unilateral vestibular deficit vertigo, facial paralysis. Management is divided into 3 options: monitoring, surgery and gamma-knife radiosurgery. This study will focus on gamma-knife radiosurgery. The objective of this treatment is to stabilize the evolution of schwannoma. This study aims to describe the vestibular effects of radiosurgery.
Interventions
OTHERVestibular exam
Interrogation, videonystagmoscopy, videonystagmography, video-head-impulse-test
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Prognostic cohort study
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
: * Men and women aged 18 to 90 included * Subject who benefited from gamma-knife radiosurgery as part of the treatment of vestibular schwannoma * Non-opposition of the subject to participate in the study * Affiliation to a French social security scheme or beneficiary of such a scheme
Exclusion criteria
: * Subject with another vestibular pathology * Subject who did not benefit from a vestibular assessment before treatment with gamma-knife radiosurgery * Legal incapacity or limited legal capacity * Subject unlikely to cooperate in the study and/or weak cooperation anticipated by the investigator * Subject without health insurance * Subject being in the period of exclusion from another study or provided for by the national volunteer file.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Description of vestibular function with videonystagmography before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma. | 1 month before gamma-knife radiosurgery | Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage) |
| Description of vestibular function with vidéonystagmoscopy before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma. | After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment | Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Description of vestibular symptoms before gamma-knife radiosurgery as part of the treatment of vestibular schwannoma. | 1 month before gamma-knife radiosurgery | Dizziness Handicap Inventoryquestionnaire (DHI questionnaire) |
| Description of vestibular symptoms after gamma-knife radiosurgery as part of the treatment of vestibular schwannoma. | After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment | Dizziness Handicap Inventoryquestionnaire (DHI questionnaire) |
Countries
France
Contacts
Primary ContactMylene ABISSE, MD
Backup ContactPOZET Astrid
Outcome results
None listed