Gabapentin, Knee Arthroscopy, Postoperative Pain, Spinal Anesthesia, Tramadol
Conditions
Brief summary
The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.
Detailed description
Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic. Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics. Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety. Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors
Interventions
DRUGGabapentin
Patients will receive oral gabapentin 600 mg 1 hour before the surgery.
DRUGTramadol
Patients will receive oral tramadol 100 mg 1 hour before the surgery.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-65 years old. * Both sexes. American Society of Anesthesiologists (ASA) physical status I and II * Undergoing knee arthroscopy procedures. * under spinal anesthesia.
Exclusion criteria
* Cardiac patients. * Patients with known allergy to drug of study. * Prolonged administration of NSAIDS or other analgesics due to chronic pain of any reason. * Cirrhosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The intensity of postoperative pain | 24 hours postoperatively | Assessment of postoperative pain will be done with a analogue scale (VAS; 0=no pain and 10=worst possible pain). At discharge post-operative and every 2 hours postoperative till 12hours then every 6 hours for the first 24 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The total amount of morphine consumption in the first 24-hour postoperative | 24 hours postoperatively | Rescue analgesia in the form of 3 mg of IV morphine will be given if the visual analog scale (VAS) score\> 3. |
| The time first rescue analgesia | 24 hours postoperatively | Rescue analgesia in the form of 3 mg of IV morphine will be given if the visual analog scale (VAS) score≥ 4. |
| The incidence of side effects | 24 hours postoperatively | Any undesirable side effects during the first 24 hours will be recorded such as as nausea, vomiting &hypotension. |
Countries
Egypt
Outcome results
None listed