Vaccine Breakthrough Infections
Conditions
Brief summary
In this study, the poly vaccination of military personnel prior to deployment will be analyzed in terms of central, peripheral and long-lasting changes in innate immunity. Analysis of monocyte immune training induced by vaccination will provide a better understanding of the indirect effects of vaccination and their persistence over time.
Interventions
Collecting blood and saliva sample
OTHERSurvey
Collecting data on infectious diseases during the study period
Sponsors
Direction Centrale du Service de Santé des Armées
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* french military personnel * \>18yo * overseas deployment scheduled between 30 and 60 days after vaccination session * adult * able to give consent
Exclusion criteria
* unrectified military personnel * having received a live vaccine within 6 months prior to inclusion * having received an attenuated vaccine within 3 months prior to inclusion * pregnancy or breastfeeding * vaccine contraindication * major incapacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Monocytes' functional reprogramming | 11 months | describing the functional reprogramming of monocytes following vaccination sessions among military personnel prior and after deployment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identify immune signatures | 11 months | Identifying immune signatures by comparing the functional reprogramming of monocytes by different vaccines and co vaccinations schemes |
| Time persistence | 11 months | Assess the persistence over time of the effects by follow-up after return from mission |
Outcome results
None listed