Knee Osteoarthritis
Conditions
Keywords
Stromal vascular fraction
Brief summary
The purpose of this study was to analyze and study the efficacy and safety of autologous adipose-derived vascular matrix components (SVF) in patients with knee osteoarthritis before and after treatment through clinical evaluation, radiation index, and metabolic index comparison between plasma and irrigation solution before and after SVF injection.
Interventions
BEHAVIORALStromal vascular fraction,SVF
SVF was injected into the knee cavity
Sponsors
Xijing Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* The age range is 20-70 years old * Patients with unilateral or bilateral knee degenerative inflammation (KOA) with Kellgren-lawrence rating of level 3 or lower * The physical health status is mainly in the ASA grade Ⅰ, Ⅱ and Ⅲ * Subjects had no active tumors, no active inflammation, no treponema pallidum, HIV, hepatitis B virus, or hepatitis C virus * The subject shall provide the physical examination report of knee X-ray examination, MRI examination and other items
Exclusion criteria
* Patients with nonunion or displaced fractures around defective cartilage * Pregnant or lactating women * Autoimmune disease * Subjects with diabetes (exceptions are patients whose blood sugar levels remain within the normal range and diabetes has not caused other complications) * The patients had severe neurological diseases affecting the evaluation of postoperative results
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T2 mapping | 24 months after the first SVF injection into the knee cavity | The degree of change of articular cartilage was observed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Western Ontario and McMaster Universities Arthritis Index (WOMAC) | 24 months after the first SVF injection into the knee cavity | The WOMAC is a specific assessment scale for osteoarthritis, which is assessed according to three aspects: pain, stiffness and function. A total of 24 WOMAC scores were scored, 0-10 points for each item, with a total score of 240 points. A total score \<80 was mild OA, a total score of 80-120 was moderate OA, and a total score of \>120 was severe OA.The severity and therapeutic effect of arthritis were evaluated according to the relevant symptoms and signs of patients. |
Countries
China
Contacts
Primary ContactYanyan Jia
Outcome results
None listed