Pancreatic
Conditions
Brief summary
This is an observational study of patients diagnosed with pancreatic cancer by pathology, with a control group of patients with pathology suggestive of benign pancreatic lesions and normal subjects, and the diagnostic ability of exosomes to identify patients with pancreatic cancer was assessed through the detection of exosomes in the peripheral blood.
Interventions
None listed
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Diagnosis of pancreatic cancer confirmed by imaging (case) Diagnosis of chronic pancreatitis confirmed by imaging (hospital control)
Exclusion criteria
The pathology diagnosis and imaging does not matched Patients with other malignant tumors Patients with other severe systemic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Characterization of proteins in tumor exosomes from patients with pancreatic cancer | Up to 2 years from start of study | We will select specific protein A from circulating exosomes of pancreatic cancer patients for further analysis. |
| The expression of protein A in the circulating exosomes from patients | Up to 2 years from start of study | By detecting the expression of protein A in circulating exosomes of patients. the ROC curve of A+ circulating exosomes will be compared to clinical standard tumor biomarkers (e.g., CA199) in pancreatic cancer patients. |
Countries
China
Outcome results
None listed