Acute Kidney Injury, Liver Transplant; Complications
Conditions
Keywords
terlipressin, Liver Transplant
Brief summary
The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation. Patients were randomly divided into experimental group and control group by numerical randomization table. The experimental group was injected with terlipressin perioperative and the control group was injected with placebo
Detailed description
acute kidney injury is a relatively common complication in patients with liver transplantation. Most centers have established prediction models for acute kidney injury after liver transplantation, but the incidence cannot be reduced through perioperative anesthesia management. As an vasopressin receptor agonist, terlipressin can increase blood pressure and improve kidney perfusion at the same time, and perioperative application may reduce the incidence of postoperative acute kidney injury
Interventions
DRUGTerlipressin
The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins
DRUGnormal saline
The medication is dispensed by the nursing staff before surgery and given to the anesthesiologist before the procedure begins
Sponsors
Beijing Tsinghua Chang Gung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 1\) Patients who plan to undergo liver transplantation in our hospital 2) Patients or family members sign informed consent
Exclusion criteria
* Patients \<18 years old;② Patients undergoing autologous liver transplantation or combined transplantation;③ Patients with lower extremity artery stenosis;(4) Patients with severe heart disease、lung disease、kidney disease;⑤ Patients with severe lung disease;⑥ Patients who used renal replacement therapy before surgery;⑦ the depth of one kidney from the body surface is greater than 4cm;⑧ Patients treated with terlipressin within 2 weeks before surgery⑨ Patients allergic to terlipressin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of acute kidney injury after liver transplantation | in 7 days | acute kidney injury diagnostic criteria (2012 edition) |
Countries
China
Contacts
Primary ContactZiheng Qi, Doctor
Outcome results
None listed