Acute Hypercapnic Respiratory Failure
Conditions
Brief summary
The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.
Detailed description
Patients presenting via Emergency Room or inpatients who are noted to be in acute hypercapnic respiratory failure will be approached for consent and if they are agreeable will be randomized to the standard of care arm which would be the use of Bilevel Positive pressure ventilation via face mask vs the intervention arm which would use the Biphasic Cuirass Ventilation. Patients will be monitored and treated in the Medical ICU and will be regularly clinically assessed as per usual standard of care. The study investigators will obtain periodic Arterial/Venous Blood gas sampling to assess for improvement or lack thereof in patients Carbon dioxide levels. If patients' condition doesn't improve or deteriorates their primary treating physician will have full authority to withdraw such patients from study and or change the modality of the patient's treatment. This is a pilot study, and the investigators are aiming to compare the success rate of Biphasic cuirass ventilation when compared to non-invasive positive pressure ventilation.
Interventions
DEVICEIntervention Arm (Biphasic cuirass ventilation)
Patients in this arm will be placed on Biphasic cuirass ventilation
Sponsors
University of Missouri-Columbia
Hayek Medical
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
can't be done as the two devices are completely different.
Intervention model description
eligible patients will be randomized to either the conventional arm (non invasive positive pressure ventilation) vs the intervention arm using the Biphasic Cuirass Ventilation.
Eligibility
Sex/Gender
ALL
Age
21 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* admission diagnosis of hypercapnic respiratory failure * pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample.
Exclusion criteria
* age \<21 * Pregnant * Inmate/Prisoner * Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery) * Chest wall defect, neuromuscular disease or diaphragmatic paralysis. * BMI \>50
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Resolution of Hypercapnic Respiratory Failure | 1-3 days | Resolution of Hypercapnic Respiratory failure will be assessed and compared with the current standard of care which is non invasive positive pressure ventilation using Arterial or Venous Blood Gas analysis. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORDennis Chairman, MD
University of Missouri-Columbia
Outcome results
None listed