Metabolism; Disorder, Postprocedural, Post Operative Nutrition, Resting Metabolic Rate
Conditions
Brief summary
This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.
Detailed description
Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks. This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery. Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.
Interventions
OTHERPre-surgical nutrition, hydration, RMR, and body composition assessments
Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
OTHERPost-surgical nutrition, hydration, RMR and body composition assessments
Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.
Sponsors
University of Kansas Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any individual over 15 undergoing an orthopedic surgery.
Exclusion criteria
* Pregnant female * \< 15 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine the magnitude of the change in RMR of patients receiving orthopedic surgery. | 12 weeks | RMR = (9.99 X actual weight\*)+ (6.25 X height\*) - (4.92 X age) - 161\*use weight in kilograms (kilogram), height in centimeters (cm). |
| To observe the amount of time it takes the RMR to return to baseline. | 12 weeks | calculation in number of weeks |
Countries
United States
Contacts
CONTACTSharon Bradshaw
Outcome results
None listed