Acute Coronary Syndrome
Conditions
Keywords
Cardiac rehabilitation, Physical activity, Force-velocity profile, Autonomic nervous system, Coronary artery disease
Brief summary
Cardiac readaptation aims to mitigate cardiovascular risks and enhance the quality of life among coronary patients. Our research laboratory has an international expertise in training optimization in top-athletes and a previous study has demonstrated the efficacy of optimizing cardiac rehabilitation through the power-force-velocity profile (PFVP). The findings exhibited significant improvements in aerobic capacity, muscular strength, and cardiovascular parameters among patients who were trained based on their PFVP. Guided training utilizing heart rate variability (HRV) is also garnering increasing interest as a means to optimize training load and promote recovery
Detailed description
Our study aims to evaluate the application of HRV in regulating training load based on fatigue levels in cardiac rehabilitation patients utilizing the PFVP framework.
Interventions
OTHERtraining strategy with adaptation of training strategies to the ANS
a training strategy for subjects whose PFVP is in favour of strength or speed with training load adjusted according to SNA
OTHERtraining strategy (standard practice)
a training strategy for subjects whose PFVP is in favour of strength or speed
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18 * Acute Coronary Syndrome treated in the last 6 months * Medical revascularization (angioplasty ± stenting) or surgical (coronary artery bypass) * Initial CPETt: MPA ≥ 60w in women and ≥80w in men * French * Informed consent
Exclusion criteria
\- Significant co-morbidities limited practice of physical activity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The root mean square of successive differences in heart rate or RMSSD | Baseline to 2 months | The root mean square of successive differences in heart rate or RMSSD will be measured from a nocturnal Holter ECG recording at the end of 8 weeks of exercise retraining and compared with the initial pre-training value. weeks of exercise re-training and compared with the initial pre-training value. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Value of maximum oxygen consumption | Baseline to 2 months | VO2 max (ml/min/kg) thanks to 24-hour ECG recording |
| Assessment of the ANS sympathetic branch | Baseline to 2 months | Assessment of the ANS sympathetic branch thanks to SDNN index value |
| Assessment of the ANS parasympathetic branch | Baseline to 2 months | Assessment of the ANS parasympathetic branch thanks to RMSSSD index value |
| non-invasive measurement of arterial stiffness | Baseline to 2 months | value of pulse wave propagation velocity |
| measurement of upper and lower limb muscle strength | Baseline to 2 months | it's a composite outcome : * measurement of handgrip (kg) thanks to Jamar hydraulic hand dynamometer * measurement maximum quadriceps strength (kg) thanks to Contrex, Physiomed |
| assessment of PFVP evolution | Baseline to 2 months | assessment of PFVP evolution thaks to cycloergometer sprint (Monark, Vansbro) |
| assessment of physical a activity and sedentary behavior | Baseline to 2 months | it's a composite outcome : * assessment of physical a activity and sedentary behavior thanks to actimetry (Actigraph GT9x) * assessment of physical a activity and sedentary behavior thanks to Adult Physical Activity Questionnaire (APAQ) |
| quality of life assessment | Baseline to 2 months | it's a composite outcome : * with mental quality of life score * with physical quality of life score |
| assessment of subjective fatigue | Baseline to 2 months | assessment of subjective fatigue thanks to FACIT-F questionary |
| biological data | Baseline to 2 months | it's a composite outcome : complete blood biology and relevant inflammatory biomarkers involved in cardiac rehabilitation. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORDavid HUPIN, MD
Centre Hospitalier Universitaire de Saint Etienne
Outcome results
None listed