Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06107166

Enrollment

Registered

2023-10-30

Start date

2018-06-01

Completion date

2021-12-31

Last updated

2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Chronic Kidney Diseases

Brief summary

Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 51 Years

Healthy volunteers

Inclusion criteria

* female sex * a diagnosis of chronic kidney disease or end stage kidney disease * age 18-51

Exclusion criteria

Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.

Design outcomes

Primary

Measure	Time frame
Pulse wave velocity	Measured at baseline
Aortic augmentation index	Measured at baseline
Flow mediated dilation	Measured at baseline
Velocity time integral	Measured at baseline

Countries

Canada

Outcome results