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Which Factors Are Relevant for Treatment Outcome in Dialectical Behaviour Therapy for Borderline Personality Disorder?

Vilka Faktorer påverkar Behandlingsutfall Vid Dialektisk Beteendeterapi för Borderline Personlighetssyndrom?

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06106555
Enrollment
100
Registered
2023-10-30
Start date
2023-09-01
Completion date
2027-08-31
Last updated
2025-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Borderline Personality Disorder, Deliberate Self Harm, Non-suicidal Self-injury

Keywords

Borderline Personality Disorder, Dialectical Behavior Therapy, Deliberate Self-Harm, Non-suicidal Self-injury, Self-concept, Personality

Brief summary

The objective of this project is to investigate factors that contribute to the success and lack of success in DBT among individuals with BPD and a history of self-harm in a clinical psychiatric setting. 1. Do certain personality factors and identity disturbance predict the treatment outcome of DBT in individuals with BPD? 2. Do changes in identity disturbance, self-hate, or emotion regulation mediate the treatment outcome of DBT in individuals with BPD? 3. Do specific personality profiles moderate the treatment outcomes of DBT for individuals with BPD? 4. When does the primary treatment effect occur, and does this effect persist after a 12-month follow-up period?

Detailed description

Borderline Personality Disorder (BPD) is a complex and enduring mental health condition characterized by a range of symptoms. The consequences of BPD are severe, causing individual suffering, impairments in daily functioning, and increased mortality rates. Dialectical behavior therapy (DBT) is one of the most widely used treatment models for BPD and self-harm. DBT has demonstrated positive outcomes but not all individuals benefit equally from this therapy, highlighting the need for further exploration. Specifically, there is a knowledge gap regarding what predicts positive treatment response. Research exploring this topic, has highlighted the potential significance of emotion regulation, personality profiles, self-concept, and identity disturbance in understanding the outcomes of individuals with BPD. The primary objective of this research project is to investigate the factors that contribute to the success and lack of success in DBT. All individuals referred to DBT-treatment in the Adult psychiatric clinic in Lund will be offered participation in the study. All study participants receive the same treatment as those who chose not to participate. Measures will commence after treatment contracts have been negotiated and the treatment will continue up to a maximum treatment length of one year. Data will be retrieved from databases, medical records as well as collected as self-report forms. Self-report measures will be conducted every three months, at end of treatment and at follow up 12 months after end of treatment. Data from registries and charts will be collected at time of consent and at follow up 12 months after treatment.

Interventions

BEHAVIORALDialectibal Behaviour Therapy

Standard Dialectical Behaviour Therapy of up to 12 months as described Professor Linehan

Sponsors

Department of Psychology. Lund University.
CollaboratorUNKNOWN
University of Toronto
CollaboratorOTHER
Lund University
CollaboratorOTHER
Region Skane
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
OTHER

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Borderline personality disorder as defined by the DSM-V (assessed with SCID or uquivalent). * Self-harm over the past 12 months * Offered DBT at the Lund adult psychiatric clinic

Exclusion criteria

* Unable to read or communicate in Swedish

Design outcomes

Primary

MeasureTime frameDescription
Five Self-harm Behaviour Groupings Measure (5S-HM)Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.Indirect and direct self-harm

Secondary

MeasureTime frameDescription
The World Health Organization Disability Assessment Schedule II (WHODAS 2)Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.Daily functioning and impairment
The Borderline Symptom List-23 (BSL-23)Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.Borderline symptoms
The Level of Personality Functioning Scale-Brief Form 2.0 (LPFS 2.0)Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.Personality functioning
The Personality Inventory for DSM-V Brief Form (PID-5-BF)Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.Personality structure
Hospitilization daysTreatment at end of treatment and at follow up at 24 months.Days admitted to a psychiatric ward past year

Countries

Sweden

Contacts

Primary ContactMagnus Nilsson, PhD
magnus.per.nilsson@skane.se046174925

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026