Acute Liver Injury, Pneumonia
Conditions
Keywords
Acute Liver Injury, pneumonia, Covid19
Brief summary
Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease. A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy
Detailed description
Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII . Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life. In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern. There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.
Interventions
OTHERAcute Liver Injury
To evaluate the impact of acute liver injury in patients with pneumonia on hospital stay and outcome.
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 68 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with pneumonia that developed Acute Liver Injury 2. Covid 19 pneumonia 3. Patients With acute liver injury only.
Exclusion criteria
1. Cancer 2. Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications. 3. Patients who younger than 18 yrs old 4. pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Impact of Acute liver injury due to Pneumonia | From Hospital admission date to Two Months | Analysis the impact of acute liver injury related to patients with pneumonia on hospital stay (measured by days spent in the hospital). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients with Pneumonia only | From Hospital admission date to Two Months | To evaluate the Patients with Pneumonia either developed acute liver injury or not, On Hospital Stay |
Countries
Egypt
Contacts
Primary ContactBeshoy Yousef, MSc
Backup ContactZain Elabdeen Ahmed, Professor
Outcome results
None listed