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Deep Learning Algorithm for Detecting Obstructive Coronary Artery Disease Using Fundus Photographs

Deep Learning Algorithm for Detecting Obstructive Coronary Artery Disease Using Fundus Photographs

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06102226
Enrollment
7000
Registered
2023-10-26
Start date
2021-07-01
Completion date
2024-12-30
Last updated
2023-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Artificial Heart Device User, Coronary Artery Disease

Brief summary

Artificial Intelligence, trained through model learning, can quickly perform medical image recognition and is widely used in early disease screening and assisted diagnosis. With the continuous optimization of deep learning, the application of AI has helped to discover some previously unknown associations with other systemic diseases. Artificial intelligence based on retinal fundus images can be used to detect anemia, hepatobiliary diseases, and chronic kidney disease, and to predict other systemic biomarkers. The above studies provide a theoretical basis for the application of artificial intelligence technology based on retinal fundus images to the diagnosis and prediction of cardiovascular diseases. At present, there is still a lack of accurate, rapid, and easy-to-use diagnostic and therapeutic tools for predictive modeling of coronary heart disease risk and early screening tools in China and the world. Fundus image is gradually used as a tool for extensive screening of diseases due to its special connection with blood vessels throughout the body, as well as easy access, cheap and efficient. It is of great scientific and social significance to develop and validate a model for identification and prediction of coronary heart disease and its risk factors based on fundus images using AI deep learning algorithms, and to explore the value of AI fundus images in assisting coronary heart disease diagnosis and screening for a wide range of applications.

Interventions

DIAGNOSTIC_TESTcoronary artery imaging (coronary CTA or coronary angiography)

In order to obtain the gold standard labeling for coronary heart disease, this topic will form a panel of experts on labeling, and the diagnosis will be based on coronary angiography, defined as a lesion with a stenosis of at least 50% in at least one coronary artery

Sponsors

Yong Zeng
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

Eligible participants were ≥ 18 years of age, with clinically suspected CAD, and were scheduled for coronary angiography.

Exclusion criteria

The

Design outcomes

Primary

MeasureTime frameDescription
AUCDecember 30, 2024To evaluate the algorithm performance area under the receiver operating characteristic curve (AUC) were calculated

Secondary

MeasureTime frameDescription
sensitivityDecember 30, 2024To evaluate the algorithm performance, the sensitivity were calculated
specificityDecember 30, 2024To evaluate the algorithm performance, the specificity were calculated

Countries

China

Contacts

Primary Contactyong zeng, Dr
yzeng_anzhen@163.com+8613501373114
Backup Contactyong zeng
yzeng_anzhen@163.com+8613501373114

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026