Acute Kidney Injury, Fluid Loss, Fluid Overload, Perioperative/Postoperative Complications
Conditions
Keywords
akut kidney injury, goal directed fluid therapy, peroperative fluid management, conventional fluid therapy
Brief summary
The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries. The main question\[s\] it aims to answer are: Does fluid management applied with different hemodynamic monitoring methods affect the risk of postoperative AKI? In our clinic, three different fluid management strategies are applied depending on the anesthetist experience. Acute kidney injury will be evaluated according to the postoperative AKIN classification of conventional fluid therapy and targeted fluid therapy with noninvasive or minimally invasive monitoring.
Detailed description
Our study was designed as a retrospective study. The files of patients over the age of 18 who underwent open abdominal surgery due to ASAII and III gynecological malignancy will be examined retrospectively. Patients who cannot be monitored peroperatively and who undergo HIPEC will be excluded from the study. Patients will be divided into 3 groups according to the fluid management strategy and the hemodynamic monitoring used: Group 1: patients receiving conventional fluid therapy; Group 2: patients receiving targeted fluid therapy with noninvasive monitoring; Group 3: patients receiving targeted fluid therapy with minimally invasive monitoring.
Interventions
DIAGNOSTIC_TESTAkut kidnet injury(AKI)
postoperative 24 hours
Sponsors
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* \>18 years * ASA II-III * Those with normal renal function
Exclusion criteria
* Patients in renal insufficiency * Patients with perioperative renal, ureter & bladder invasion * Patients in whom perioperative urine monitoring cannot be performed * Patients undergoing HIPEC * Patients with missing data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of acute kidney injury | Change from preoperative to postoperative day 1(POD1)creatinine values(mg/dl) | Our primary aim was to evaluate the postoperative day(POD1 ) creatinine values(mg/dl) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peroperative fluid amounts | during the operation period | The seconder aim to investigate the amount of fluid used peroperatively |
Other
| Measure | Time frame | Description |
|---|---|---|
| The intensive care unit admission | posoperatively up to 1 months | The other aim to investigate the intensive care unit admission |
| Length of stay | postoperative 30 days | The other aim to evaluate the duration of hospital stay. |
Countries
Turkey (Türkiye)
Outcome results
None listed