Skip to content

Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.

Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure in Patients With Central Nervous System Injuries. A Randomized Controlled Trial in Post-stroke Patients and a Pilot Study in Spinal Cord Injured Patients.

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06099340
Acronym
RenfExc
Enrollment
90
Registered
2023-10-25
Start date
2024-09-30
Completion date
2027-10-31
Last updated
2024-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke, Spinal Cord Injured

Keywords

Neurological rehabilitation, Physiotherapy, Eccentric muscle strengthening, Strength, Spastic paresis, Stroke, Spinal cord injury

Brief summary

Neurological disorders \[such as Cerebral Vascular Accident (CVA) or Spinal Cord Injury (SCI)\] are among the most costly health problems to society in industrialized countries. For those affected, they generate severe restrictions in mobility, significantly altering their quality of life. Deterioration in motor function after stroke or BM is closely linked to the level of force produced at joint level. This is influenced by adaptations (neurological and tissue) inherent to the pathophysiology of the injury, and characterized by the presence of a spastic paresis syndrome. A great deal of effort is devoted to motor neurorehabilitation (particularly physiotherapy) in the days and weeks following neurological injury. This so-called sub-acute rehabilitation phase is designed to have a positive impact on the patient's motor recovery (to prevent the development of spastic paresis), and to prevent future severe limitations in the long term. Disorders observed in the chronic phase (partial recovery of strength, severe orthopedic deformities) demonstrate the limits of current therapies. In view of the results obtained in healthy subjects, eccentric training now seems to be one of the most promising physiotherapy methods for recovering muscle strength and countering neurological disorders. However, its use in the sub-acute rehabilitation phase has never been evaluated in post-stroke or post-BM patients, either in terms of its effects on the strength developed in the strengthened muscles, or more locally on the neurological and tissue disorders found in these patients in the context of spastic paresis. The aim of this project is to evaluate the effects of an eccentric muscle-strengthening exercise protocol on neurological patients in the sub-acute phase of their neurological impairment. The protocol will be applied to the ankle joint, given its importance for walking and the significant deficits found at this level in neurological populations.We hypothesize that the strengthening protocol will improve muscle strength at the ankle, and generate beneficial adaptations to combat the spastic paresis syndrome (improved muscle activation, increased muscle length, muscle volume, etc.).

Interventions

OTHERmuscle-strengthening program

a muscle-strengthening program applied to the ankle muscles (triceps surae and dorsal flexors) in physiotherapy, as a complement to conventional rehabilitation

Sponsors

Nantes University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Masking description

Prospective Randomized Open Blinded End-point

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Patient aged between 18 and 80 years * Patient with stroke\< 6 months or Patient with spinal cord injury American Spinal Injury Association (ASIA) Impairment Scale C or D (incomplete motor impairment) \< 6 months (second secondary criterion). * Patient hospitalized for primary rehabilitation in the neurological PRM department of Nantes University Hospital. * Patient with voluntary motricity rated between 2 and 4 on the MRC (Medical Research Council) scale

Exclusion criteria

History of functional surgery \<3 months or intramuscular injection into plantar flexors \<6 months * Patient with osteoarticular lesions contraindicating rehabilitation * Patient unlikely to adhere to protocol (severe cognitive impairment) and/or non-compliant * Patient with a progressive pathology contraindicating efforts (syrinx, cancer, cardiovascular instability, etc.) * Minors, protected adults, adults unable to give consent or pregnant women.

Design outcomes

Primary

MeasureTime frameDescription
Maximum joint force moment10 weeks after the start of the muscle-strengthening protocolThe force-generating capacity of the plantar flexors will be studied by measuring the maximum joint force moment on an isokinetic ergometer

Secondary

MeasureTime frameDescription
Measurement of joint force moment14 weeks after the start of the muscle-strengthening protocolMeasurement of joint force moment, performed on an isokinetic ergometer, in isometric condition

Countries

France

Contacts

Primary ContactRaphael Gross, PU-PH
raphael.gross@chu-nantes.fr02.40.84.62.08
Backup ContactGuillaume Le Sant
guillaume.le-sant@univ-nantes.fr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026