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Muscle Recovery After Total Knee Arthroplasty

Invastigation of the Relationship Between Early Quadriceps Arthrogenic Muscle Inhibition and Functional Recovery After Total Knee Arthroplasty

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06096792
Enrollment
20
Registered
2023-10-24
Start date
2024-10-10
Completion date
2025-09-11
Last updated
2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Arthritis, Osteoarthritis

Keywords

knee arthroplasty, Knee osteoarthritis, muscle inhibition

Brief summary

Total knee arthroplasty (TKA) surgery is a common procedure performed to reduce pain, improve function, and enhance the quality of life in patients with end-stage knee osteoarthritis. As with other knee-related injuries and surgeries, TKA surgery can lead to inhibition of the quadriceps muscle, resulting in a decrease in the muscle's capacity to generate maximum voluntary force. This issue can negatively affect post-injury rehabilitation and function. The long-term persistent neuromuscular muscle inhibition in the quadriceps, one of the most important anti-gravity muscles in our body, leads to muscle atrophy and strength loss, which is more determinant in the development of functional limitations compared to joint range of motion and knee pain. There have been no studies found that assess the quadriceps muscle inhibition occurring during the hospitalization of patients undergoing total knee arthroplasty surgery and examine its impact on post-discharge functional status. The aim of this study is to evaluate the severity of arthrogenic inhibition in the quadriceps muscle of patients following total knee arthroplasty surgery, which is widely practiced in our country and considered the gold standard for the treatment of end-stage knee osteoarthritis. Additionally, the study aims to investigate its impact on post-discharge functional recovery. The data obtained from this study will provide guidance in monitoring patients' early functional recovery post-surgery and in better planning post-surgical rehabilitation. The study will include patients aged 50-75 who have undergone total knee arthroplasty surgery due to knee osteoarthritis. Demographic information such as age, height, weight, and body mass index will be recorded. Pain will be assessed using a visual analog scale, and edema will be measured during hospitalization, at the 2nd and 6th-week follow-up visits. In addition to all the evaluations, functional status will be assessed at the 2nd and 6th-week follow-up visits using the 5-repetition sit-to-stand test, 10-meter walking test, and 2-minute walking tests, as well as knee function evaluated through the WOMAC and KOS-ADLS questionnaires.

Detailed description

The study will include patients aged 50-75 who have undergone total knee arthroplasty surgery due to knee osteoarthritis. Demographic information such as age, height, weight, and body mass index will be recorded. Pain will be assessed using a visual analog scale, and edema will be measured during hospitalization, at the 2nd and 6th-week follow-up visits. In addition to all the evaluations, functional status will be assessed at the 2nd and 6th-week follow-up visits using the 5-repetition sit-to-stand test, 10-meter walking test, and 2-minute walking tests, as well as knee function evaluated through the WOMAC and KOS-ADLS questionnaires.

Interventions

None listed

Sponsors

Hacettepe University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
50 Years to 75 Years

Inclusion criteria

* Age between 50 and 75 years. * Have undergone unilateral total knee arthroplasty surgery due to osteoarthritis. * Hemodynamically stable post-surgery. * Willing to participate in the study.

Exclusion criteria

* Having any neurological or oncological issues. * Having undergone revision surgery. * Having a history of cardiovascular surgery.

Design outcomes

Primary

MeasureTime frameDescription
muscle inhibitionpostoperative day-1; postoperative day-2; postoperative day-3; postoperative 2th week and postoperative 6th weekQuadriceps maximum isometric muscle contraction will be evaluated by measuring the pneumatic pressure change with a pneumatic dynamometer.

Secondary

MeasureTime frameDescription
Functional recoverypostoperative 2th week and postoperative 6th weekFive times sit to stand test

Countries

Turkey (Türkiye)

Contacts

PRINCIPAL_INVESTIGATORSibel Bozgeyik Bağdatlı, PhD

Hacettepe University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026