Heterogeneity and Development of Early COPD

Heterogeneity and Disease Development of Early Chronic Obstructive Pulmonary Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06096285

Enrollment

Registered

2023-10-23

Start date

2023-02-01

Completion date

2025-01-31

Last updated

2023-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary disease, Early COPD, Heterogeneity, Disease development

Brief summary

This study aims to investigate the clinical characteristics and heterogeneities of early chronic obstructive pulmonary disease (COPD), to determine the disease development of early COPD, and to establish a multidimensional model for predicting the outcomes of early COPD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* The individuals who meet the defining criteria of PRISm, COPD Stage 0, Pre-COPD, Early COPD, Young COPD, and Mild COPD, according to the latest GOLD documents and publications.

Exclusion criteria

* Age \< 18 years or \> 80 years; * Pregnant or maternal women; * Having malignant and active tumor(s), and receiving treatment; * Undergoing a surgical operation; * Having problems with mental awareness; * Having difficulties in daily activities; * Participating in other interventional clinical trials.

Design outcomes

Primary

Measure	Time frame	Description
Number of participants with COPD exacerbation	One year	COPD exacerbation refers to acute deterioration of respiratory symptoms (e.g. cough, sputum, wheeze, dyspnea), especially resulting in hospital visit or admission.

Secondary

Measure	Time frame	Description
FVC	One year	—
FEV1/FVC ratio	One year	—
FEV1% predicted value	One year	—
FEV1	One year	—
The COPD Assessment Test scale	One year	The COPD Assessment Test scores range from 0 to 40, with higher scores indicating worse symptoms.
The modified Medical Research Council dyspnea scale	One year	The modified Medical Research Council dyspnea scores range from 0 to 4, with higher scores indicating more severe dyspnea.
FVC% predicted value	One year	—

Countries

China

Contacts

Primary ContactJieping Lei, Ph.D.

jiepinglei@126.com+86 010 8420 6408

Outcome results