Unfractionated Heparin
Conditions
Brief summary
Unfractionated heparin (UFH) is an anticoagulant to prevent thrombus formation or worsening of an existing thrombus. It is indicated for patients with deep vein thrombosis/pulmonary embolism (DVT/PE) or acute coronary syndrome (ACS). Unfractionated heparin treatment consists of an initial bolus followed by a continuous infusion that is adjusted based on the patient's subsequent partial thromboplastin time (PTT) levels
Detailed description
Unfractionated heparin is classified as a high-alert medication in the acute care setting.3 Therapeutic anticoagulation is a high priority for healthcare teams because the impacts of inadequate anticoagulation can lead to life threatening events such as a major bleed or thrombus formation and/or death.
Interventions
None listed
Sponsors
Methodist Health System
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patient's aged 18 years or older with a confirmed diagnosis of DVT/PE based on imaging or a confirmed diagnosis of ACS requiring heparin therapy
Exclusion criteria
* History of bleeding in the last 30 days * History of HIT * Use of systemic anticoagulants for another indication * Presence of coagulation disorder prior to admission (i.e. hemophilia, sickle cell anemia, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidents of deviations from protocol | 30 Days | Appropriate anticoagulation management will be measured using Percent time in therapeutic range based on aPTT levels |
Countries
United States
Outcome results
None listed