Osteomyelitis
Conditions
Brief summary
Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the infectious organism
Detailed description
This disease can be classified by location of infection, extent of spread, chronicity, and source of infection.3,4 Osteomyelitis can be caused by a variety of organisms, most commonly gram-positive staphylococci. Osteomyelitis is associated with a high rate of relapse, high disease burden, and high health care costs.3 Following confirmation of disease via imaging and histopathologic examination, treatment consists of antibiotic therapy and, often, surgical intervention.3,5,6 Treatment with antibiotic therapy is often administered for 4-6 weeks when surgical intervention is not performed.6 Antibiotic selection should be guided by microbiology and antimicrobial susceptibilities.4 Thirty to sixty percent of osteomyelitis cases are caused by Staphylococcus aureus.
Interventions
DRUGAnti-MRSA therapy
chart review to determine the clinical outcomes of patients with osteomyelitis who were placed on definitive anti-MRSA treatment, despite no identified MRSA cultures.
Sponsors
Methodist Health System
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* • Admission to any MHS hospital between April 1, 2017 and April 1, 2023 * \> 18 years of age * Documented osteomyelitis location of the lower limb via ICD-10 code * Documented imaging of lower limb osteomyelitis during index admission * Planned intravenous (IV) antibiotics for at least 4 weeks
Exclusion criteria
* • IV antibiotics for less than 24 hours inpatient * Planned surgical intervention documented at admission * Patients receiving monotherapy with an anti-MRSA agent * Positive MRSA culture during index admission * Current outpatient antibiotic use on index admission * Repeated hospital admission during study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of treatment | 180 Days | the comparison of treatment failure between anti-MRSA therapy and no anti-MRSA therapy defined as a composite of hospital readmission for osteomyelitis within 180 days of antibiotic initiation |
Countries
United States
Contacts
Primary ContactBethany Brauer, MPH
Backup ContactColette Ngo Ndjom, MS
Outcome results
None listed