Autonomic Nervous System Disease, Blood Pressure, Coronary Artery Disease, Heart Rate
Conditions
Brief summary
Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.
Interventions
OTHERPlacebo Protocol
ingestion of 500 mg of starch following 30 minutes of exercise (treadmill)
OTHERProtocol Beet
ingestion of 500 mg of beet extect following 30 minutes of exercise (treadmill)
OTHERProtocol Resveratrol
ingestion of 500 mg of resveratrol following 30 minutes of exercise (treadmill)
OTHERProtocol Beet and Resveratrol
ingestion 500 mg of beet extect and 500 mg of resveratrol following 30 minutes of exercise (treadmill)
Sponsors
Universidade Estadual Paulista Júlio de Mesquita Filho
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
40 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* adult men over 45 years of age * diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram
Exclusion criteria
Volunteers who present at least one of the following characteristics will be excluded: * smokers * alcohol drinkers * those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection * individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate variability (HRV) | through study completion, an average of 1 hour | Time and frequency domain of HRV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | through study completion, an average of 1 hour | Systolic Blood Pressure and Diastolic Blood Pressure |
Countries
Brazil
Outcome results
None listed