Diabetic Nephropathy, Perioperative/Postoperative Complications, Transplant Complication
Conditions
Keywords
enhanced recovery after surgery, SPK transplantation
Brief summary
108 patients underwent elective SPK surgery were randomly divided into ERAS group (E) and routine care group (T). The ERAS group was consisted of evidenced-based systematic optimization approaches, while the control group received routine care.
Detailed description
Primary results: the postoperative length of stay (LoS) and hospitalization costs; second results: post-operative analgesia score (NRS) , the incidence of post-operative nausea and vomiting (PONV) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days . the dosage of dobutamine using , the dosage of norepinephrine using, and the total amount of fluid and urine volume . MAP and lactate level . Peak systolic velocity (PSV) and (resistance index) RI of grafts were checked between two groups.
Interventions
PROCEDUREEnhanced recovery for SPK recipients
Pre-operative, perioperative and post-operative were consisted of evidenced-based systematic optimization approaches.
Sponsors
Second Affiliated Hospital of Guangzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
prospective randomized controlled tiral
Eligibility
Sex/Gender
ALL
Age
20 Years to 62 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients were aged 20-62 years 2. Body mass index (BMI) of 18.5-32.9 kg/m2 3. Voluntary participation for elective SPK surgery 4. ERSD and DN patients waiting for SPK transplantation surgery.
Exclusion criteria
1. History of allergy to narcotic drugs 2. cardiopulmonary insufficiency 3. congestive heart failure 4. myasthenia gravis 5. neurological disease 6. mental illness 7. severe liver dysfunction 8. hyperkalaemia 9. malignant hyperthermia 10. unwilling to participate in the study for any reason, or had participated in another study within the 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hospital costs (US dollar) | Total costs(dollar) of the patients spended from the day of admiting to hospital to the day of discharge from hospital(days). | The total cost of treatment for the patients. |
| Length of hospital stay (LoS) | Record all the period time from the day of admiting to hospital to the day of discharge from hospital(days). | Record the time for SPK recipients of LoS (days) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative complications | After the surgery acomplishment(see detail above)：record the NRS within 40hours after the surgery, occurrence rate of the PPCs within 2 weeks after the surgery, ocurrence rate of the ambulation within 6 days after the surgery, etc. | 48 hours post-operative analgesia score (NRS), the incidence of post-operative nausea and vomiting (PONV) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days |
Countries
China
Outcome results
None listed