Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Conditions
Keywords
ECMO, Thrombosis, Haemorrhage
Brief summary
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
Interventions
DIAGNOSTIC_TESTDIC markers and Thrombin Generation Parameters
Observation of DIC markers and thrombin generation parameters in patients with and without thrombotic and hemorrhagic complications
Sponsors
Queen Mary Hospital, Hong Kong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age ≧ 18; AND * Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND * Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support.
Exclusion criteria
* Patients who are on central VA-ECMO support; OR * Patients with missing clinical data; OR * Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR * Post-operative admissions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composite of thrombotic and hemorrhagic events | From the start of ECMO support to the end of ECMO support (which can be variable, typically around 5 days to 1 week) | Thrombotic events include circuit-related thrombosis (e.g. oxygenator failure requiring circuit change) OR Non-circuit-related thrombosis (e.g. new pulmonary embolism or deep vein thrombosis while on ECMO. Hemorrhagic events include bleeding at critical sites or requiring interventions. |
Countries
Hong Kong
Outcome results
None listed