Hydrogen Sulfide, Osteoporosis
Conditions
Brief summary
The aim of the study is to investigate whether inhalation treatment with high-sulfide waters from some spas (referred to as thermal waters), performed for 12 consecutive days, is able to change circulating H2S levels and alter bone metabolism. Identifying a clear correlation between circulating levels of H2S and sulfur water administration, as well as a potential anabolic effect on bone, would set the stage for new studies that could have important clinical implications for promoting health and preventing osteoporosis
Interventions
OTHERinhalatory treatment with sulfureous aerosol
osteopenic patients are subject to a 12-days cycle of 30 minutes-long inhalatory treatment with sulfureous aerosol
Sponsors
Istituto Ortopedico Rizzoli
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* post-menopausal women with a diagnosis of osteopenia
Exclusion criteria
* concurrent muscoloskeletal conditions or chronic pharmacological treatment interfering with bone metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of biomarkers of bone turnover, marker #3 | 15 days | serum C-terminal telopeptide of type I collagen (CTX-1), marker of bone resorption |
| Measurement of biomarkers of bone turnover, marker #1 | 15 days | Procollagen type 1 N-terminal propeptide (P1NP), marker of bone formation |
| Measurement of biomarkers of bone turnover, marker #2 | 15 days | Bone-specific alkaline phosphatase (BAP), marker of bone formation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of serum H2S levels | 15 days | serum H2S levels will be assessed through HPLC |
Countries
Italy
Outcome results
None listed