Hip Disease
Conditions
Keywords
Hip dysplasia, Acetabular protrusion, Deep hip, Acetabular retroversion
Brief summary
In this study, the investigators seek to describe the normal 3D hip joint morphology in asymptomatic volunteers and compare it to various hip joint deformities. Asymptomatic volunteers will be asked to undergo a non-contrast MRI of the hip at 3 Tesla, utilizing a high-resolution morphologic 3D sequence (3D T2 DESS) that enables the segmentation of labrum and cartilage. 3D morphological parameters of the asymptomatic group will subsequently be compared with the 3D morphological parameters of patients with hip deformities, which were collected as part of a previous retrospective study.
Detailed description
Hip deformities can cause hip pain and early onset osteoarthritis in young individuals. Correcting these deformities typically involves planning with X-rays and MRI images, which offer a limited view of the hip joint's 3D structure. A comprehensive 3D analysis of hip structures, including cartilage, and labrum, would enhance diagnosis and surgery planning. However, 3D hip morphology hasn't been adequately described for distinguishing deformities. The aim of this study is to describe normal 3D hip joint morphology in healthy participants and compare it to various hip joint deformities (Dysplasia, acetabular protrusion, retroversion, deep hip, and cam deformity). Asymptomatic volunteers will undergo a non-contrast MRI of the hip at 3 Tesla using high-resolution morphologic 3D sequence (3D T2 DESS), which allows segmentation of labrum and cartilage. The 3D morphological parameters of the asymptomatic group will then be compared with those of patients with hip deformities, data sourced from a retrospective study that included 100 patients from the outpatient clinic. These patients underwent direct MR arthrography at 3 Tesla in accordance with the institutional routine protocol at the Department of Diagnostic, Interventional, and Pediatric Radiology at Inselspital.
Interventions
OTHERNon- contrast Magnetic Resonance Imaging (MRI) of the hip
Asymptomatic volunteers will undergo a non-contrast MRI of the hip at 3 Tesla. Following this, MRI images will be automatically segmented utilizing a validated artificial intelligence based algorithm to calculate 3D outcome parameters.
OTHERMagnetic Resonance Imaging (MRI) of the hip with intra-articular contrast agent
The data was derived from a retrospective study involving patients at Inselspital's outpatient clinic who underwent 3 Tesla hip MRI scans with intra-articular contrast agent. A validated artificial intelligence based algorithm was utilized for automated segmentation and the calculation of 3D outcome parameters.
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18 years. * Signed an informed consent form. * History free of significant hip pain, with no history of juvenile hip disease, traumatic injuries, inflammatory conditions, or tumors affecting the hip. * Normal clinical examination of the hip.
Exclusion criteria
Individuals who are not considered suitable for MRI (Magnetic Resonance Imaging) for the following reasons: * Potential pregnancy * Presence of metal fragments in the eye or elsewhere in the body * Presence of implants and metallic foreign bodies, such as a pacemaker, heart valve, cerebrospinal fluid shunt, insulin pump, nerve stimulator, or cochlear implant * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Labrum Volume | Within 12 Months after MRI | Difference in hip labrum volume (mm³) between healthy volunteers and patients with hip deformities. |
| Cartilage Surface Area | Within 12 Months after MRI | Difference in hip cartilage surface area (both absolute - mm² and relative - %) between healthy volunteers and patients with hip deformities. |
| Cartilage Thickness | Within 12 Months after MRI | Difference in hip cartilage thickness (mm) between healthy volunteers and patients with hip deformities |
| Cartilage Orientation | Within 12 Months after MRI | Difference in hip cartilage orientation, measured in inclination (°) and anteversion (°), between healthy volunteers and patients with hip deformities. |
| Cartilage Volume | Within 12 Months after MRI | Difference in hip cartilage volume (mm³) between healthy volunteers and patients with hip deformities. |
| Labrum Length | Within 12 Months after MRI | Difference in labrum length (mm) between healthy subjects and patients with hip deformities. |
| Labrum Area | Within 12 Months after MRI | Difference in hip labrum surface area (both absolute - mm² and relative - %) between healthy volunteers and patients with hip deformities. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| iHOT 12 Questionnaire | ca. 5 minutes before MRI | The iHOT-12 is a validated questionnaire for young, active individuals with early hip disease. It covers four domains: symptoms and limitations, sports and recreation, job concerns, and social/emotional aspects. Responses are marked on a 100-mm scale, with the total score as a simple mean ranging from 0 to 100, where 100 represents the best possible quality of life. |
Countries
Switzerland
Contacts
Primary ContactJose A. Roshardt, Dr.
Outcome results
None listed