Ankylosing Spondylitis
Conditions
Keywords
Ankylosing spondylitis, atherosclerosis, epicardial adipose tissue thickness
Brief summary
The aim of this study was to assess the EATT and the related factors in patients with AS and to compare the results with that of the healthy controls'
Detailed description
The aim of this study was to investigate the epicardial adipose tissue thickness (EATT) and the related factors in patients with ankylosing spondylitis (AS) and to compare the results with those of the healthy controls. This cross-sectional study comprised thirty patients diagnosed with AS based on the modified New York criteria. The control group consisted of 31 healthy volunteers. Demographic characteristics were recorded. EATT was measured via transthoracic echocardiography. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Ankylosing Spondylitis Quality of Life (ASQoL), International Physical Activity Questionnaire Short Form (IPAQ-Short Form) were used. Functional capacity assessment was conducted using the six-minute walk test (6MWT).
Interventions
DIAGNOSTIC_TESTepicardial adipose tissue thickness
EATT measured via transthoracic echocardiography
Sponsors
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Disease duration \>1 year, * Being ≥18 years * AS diagnosis according to modified New York Criteria
Exclusion criteria
* Being illiterate, * \>65 years, * History of ischemic heart disease, * Cerebrovascular disease, * Hypertension, * Chronic kidney failure, * endocrinopathies like diabetes mellitus, * hypothyroidism, * Cushing syndrome and primary hyperlipidemia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epicardial adipose tissue thickness | through study completion, an average of 5 months | Epicardial adipose tissue thickness is measured via transthoracic echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bath Ankylosing Spondylitis Disease Activity Index | through study completion, an average of 5 months | The index indicates that disease activity of AS patients. Higher scores indicate that higher activity |
| Bath Ankylosing Spondylitis Functional Index | through study completion, an average of 5 months | The index helps to evaluate disease activity of AS patients. High scores indicate that worse functional status. |
| Bath Ankylosing Spondylitis Metrology Index | through study completion, an average of 5 months | The index helps to evaluate spinal mobility of AS patients. Higher scores indicate more limited mobility. |
| Ankylosing Spondylitis Quality of Life | through study completion, an average of 5 months | it is used for evaluate quality of life of AS patients. A lower score indicates better quality of life |
| Six minute walk test | through study completion, an average of 5 months | This test is used to evaluate the patient's functional capacity. In case of low functional capacity, lower scores are observed. Higher scores indicate that higher activity. |
| International Physical Activity Questionnaire Short Form | through study completion, an average of 5 months | it is used for evaluate patient's physical activity. Scoring a high level of physical activity on the IPAQ means your physical activity levels equate to approximately one hour of activity per day or more at least a moderate intensity activity level. |
| Ankylosing Spondylitis Disease Activity Score | through study completion, an average of 5 months | This score is used to evaluate disease activity of AS patients. Higher scores indicate that higher activity. |
Countries
Turkey (Türkiye)
Outcome results
None listed